Interplay of prefrontal cortex and amygdala during extinction of drug seeking

Brain Structure & Function
Valeria OlivaGianluca Baldassarre

Abstract

Extinction of Pavlovian conditioning is a complex process that involves brain regions such as the medial prefrontal cortex (mPFC), the amygdala and the locus coeruleus. In particular, noradrenaline (NA) coming from the locus coeruleus has been recently shown to play a different role in two subregions of the mPFC, the prelimbic (PL) and the infralimbic (IL) regions. How these regions interact in conditioning and subsequent extinction is an open issue. We studied these processes using two approaches: computational modelling and NA manipulation in a conditioned place preference paradigm (CPP) in mice. In the computational model, NA in PL and IL causes inputs arriving to these regions to be amplified, thus allowing them to modulate learning processes in amygdala. The model reproduces results from studies involving depletion of NA from PL, IL, or both in CPP. In addition, we simulated new experiments of NA manipulations in mPFC, making predictions on the possible results. We searched the parameters of the model and tested the robustness of the predictions by performing a sensitivity analysis. We also present an empirical experiment where, in accord with the model, a double depletion of NA from both PL and IL in CPP with amphetamine ...Continue Reading

References

Jul 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S ErbJ Stewart
Jul 17, 2004·The European Journal of Neuroscience·Sebastien Bouret, Susan J Sara
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Jeffrey W DalleyTrevor W Robbins
Dec 13, 2006·The European Journal of Neuroscience·Nina C Di PietroKathleen M Kantak
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rossella VenturaStefano Puglisi-Allegra
Apr 21, 2007·The European Journal of Neuroscience·S E V Rhodes, A S Killcross
May 10, 2007·Nature Protocols·Christopher L CunninghamPeter A Groblewski
Oct 25, 2007·Current Biology : CB·Joseph LeDoux
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie PetersPeter W Kalivas
Jul 11, 2008·Nature·Cyril HerryAndreas Lüthi
Aug 30, 2008·PloS One·Rossella VenturaStefano Puglisi-Allegra
Feb 5, 2009·Nature Reviews. Neuroscience·Susan J Sara
Apr 22, 2009·Learning & Memory·Jamie PetersGregory J Quirk
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony Burgos-RoblesGregory J Quirk
Nov 7, 2009·Cerebral Cortex·Jennifer R St Onge, Stan B Floresco
Nov 26, 2009·Behavioural Brain Research·Devin Mueller, Shawn P Cahill
Nov 26, 2009·Neuroscience and Biobehavioral Reviews·Michel C Van den OeverTaco J De Vries
Mar 9, 2010·Nature Neuroscience·Taiju AmanoDenis Paré
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Demetrio Sierra-MercadoGregory J Quirk
Nov 16, 2010·Behavioural Brain Research·E Zayra MillanGavan P McNally
Mar 12, 2011·Biological Psychiatry·Rick E LaughlinJ David Jentsch
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniela BustiFrancesco Ferraguti
Aug 23, 2011·Neurobiology of Learning and Memory·Raymond P Kesner, John C Churchwell
Sep 20, 2011·Nature Neuroscience·William H Alexander, Joshua W Brown
Feb 11, 2012·The European Journal of Neuroscience·Ryan T LaLumierePeter W Kalivas

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Citations

Nov 6, 2018·Psychopharmacology·Wen-Hua ZhangYan-Xue Xue
Aug 3, 2019·Physiological Genomics·Pan XuHui Lu
Nov 3, 2020·Frontiers in Systems Neuroscience·Andrea MatteraGianluca Baldassarre

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