Interplay of reverse transcriptase inhibitor therapy and gag p6 diversity in HIV type 1 subtype G and CRF02_AG.

AIDS Research and Human Retroviruses
Akinyemi I OjesinaPhyllis J Kanki

Abstract

Abstract The gag p6 region of HIV-1 has various nonsubstitutionary mutations, including insertions, duplications, deletions, and premature stop codons. Studies have linked gag p6 mutations to reduced susceptibility to antiretroviral therapy in HIV-1 subtype B. This study examined the relationship between antiretroviral therapy and gag p6 diversity in HIV-1 CRF02_AG and subtype G. p6 data were generated for secondary analyses following Viroseq genotyping of pol gene sequences in plasma samples from HIV-1-infected Nigerians on reverse transcriptase inhibitor therapy, with virologic failure (repeat VL > 2000 copies/ml). p6 sequence chromatograms were available for 40 CRF02_AG and 43 subtype G-infected individuals. Subjects who had not received their supply of antiretroviral drugs for at least 2 months prior to the plasma sampling were classified as nonadherent. p6 sequences from therapy-adherent individuals had more nonsubstitutionary mutations than sequences from drug-naive individuals (p = 0.0005). The P5L/T mutation was inversely correlated with the presence of K27Q/N in p6, with each mutation being more prominent in subtype G and CRF02_AG, respectively. The data also suggested that P5L/T may be a compensatory mutation for the ...Continue Reading

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Citations

Mar 6, 2013·AIDS Research and Human Retroviruses·Andres H RossiPaula C Aulicino
Dec 22, 2016·The Journal of Antimicrobial Chemotherapy·K KletenkovUNKNOWN Swiss HIV Cohort Study

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Methods Mentioned

BETA
Genotyping

Software Mentioned

DNAS
ViroSeq System
Viroseq
Clustal X
TAR SeqMan II
PAUP
Se
MacClade

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