Interplay of spinal and vagal pathways on esophageal acid-related anterior cingulate cortex functional networks in rats.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Patrick SanvansonReza Shaker

Abstract

Esophageal acid sensory signals are transmitted by both vagal and spinal pathways to the cerebral cortex. The influence and interplay of these pathways on esophageal acid-related functional connectivity has been elusive. Our aim was to evaluate the esophageal acid exposure-related effect on the anterior cingulate cortex (ACC) functional connectivity networks using functional MRI-guided functional connectivity MRI (fcMRI) analysis. We studied six Sprague-Dawley rats for fcMRI experiments under dexmedetomidine hydrochloride anesthesia. Each rat was scanned for 6 min before and after esophageal hydrochloric acid infusion (0.1 N, 0.2 ml/min). The protocol was repeated before and after bilateral cervical vagotomy on the same rat. Seed-based fcMRI analysis was used to examine ACC networks and acid-induced network alterations. Three-factor repeated-measures ANOVA analysis among all four subgroups revealed that the interaction of acid infusion and bilateral vagotomy was mainly detected in the hypothalamus, insula, left secondary somatosensory cortex, left parietal cortex, and right thalamus in the left ACC network. In the right ACC network, this interaction effect was detected in the caudate putamen, insula, motor, primary somatosensor...Continue Reading

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Citations

Feb 11, 2021·Neuroscience Bulletin·Xiao XiaoYu-Qiu Zhang

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Methods Mentioned

BETA
sedation

Software Mentioned

Analysis of Functional NeuroImages AFNI Centre for Functional ...
Exp
AlphaSim
AFNI 3dNLfim
FLIRT
Linear Image Registration Tool ( FLIRT )
Diff
DiffExp

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