Interpregnancy interval, maternal age, and offspring's BMI and blood pressure at 7 years of age

Journal of Human Hypertension
Shenghui LiJun Zhang

Abstract

Interpregnancy interval and maternal age are associated with birth outcomes. However, it is unknown regarding their long-term effects on child health. We aim to assess the associations between interpregnancy interval and offspring's body mass index (BMI) and blood pressure (BP) at age of 7 years and to examine the role of maternal age in the associations. A secondary analysis was performed among 2604 mother-infant pairs in the prospective National Collaborative Perinatal Project, in which the children were followed up until 7 yrs of age. Interpregnancy interval was positively associated with offspring's diastolic BP at 7 yrs (β = 0.053, 95% CI: 0.004-0.102) after adjusting for maternal and perinatal characteristics, feeding pattern, rapid weight gain in the first year of life, and current BMI z score and height z score. The inclusion of maternal age in the model did not change the effect size. Maternal age was independently associated with offspring's BMI z score at 7 yrs (β = 0.014, 95% CI: 0.001-0.027). An interaction between interpregnancy interval and maternal age was present in the association with diastolic BP (P = 0.019), and the increasing maternal age aggravated the effects of long interpregnancy interval. Our finding ...Continue Reading

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Citations

Mar 19, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Aaron M MooreJack A Taylor
May 30, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elizabeth J TaylorNisreen A Alwan
Dec 2, 2020·Journal of Clinical Medicine·Joanna BaranArtur Mazur

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