Interpretable brain age prediction using linear latent variable models of functional connectivity

PloS One
Ricardo Pio MontiAapo Hyvarinen

Abstract

Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on functional connectivity while prioritizing model interpretability and understanding. This way, the models serve to both provide accurate estimates of brain age as well as allow us to investigate changes in functional connectivity which occur during the ageing process. The methods proposed in this work consist of a two-step procedure: first, linear latent variable models, such as PCA and its extensions, are employed to learn reproducible functional connectivity networks present across a cohort of subjects. The activity within each network is subsequently employed as a feature in a linear regression model to predict brain age. The proposed framework is employed on the data from the CamCAN repository and the inferred brain age models are further demonstrated to generalize using data from two open-access repositories: the Human Connectome Project and the ATR Wide-Age-Range.

References

Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Mar 1, 2005·NeuroImage·Fabrizio EspositoFrancesco Di Salle
Aug 22, 2006·Neuroscience and Biobehavioral Reviews·Naftali Raz, Karen M Rodrigue
Oct 19, 2006·Neuroreport·Vladimir L CherkasskyMarcel Adam Just
Feb 7, 2008·IEEE Transactions on Neural Networks·A Hyvärinen
Mar 3, 2009·Magnetic Resonance Imaging·John Ashburner
Jan 15, 2010·NeuroImage·Katja FrankeUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 16, 2010·Annals of the New York Academy of Sciences·Craig M Bennett, Michael B Miller
Sep 11, 2010·Science·Nico U F DosenbachBradley L Schlaggar
Aug 16, 2011·Neurobiology of Aging·Jessica S DamoiseauxMichael D Greicius
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Jan 18, 2012·NeuroImage·Stephen M Smith
Feb 22, 2012·Trends in Cognitive Sciences·Clare KellyMichael P Milham
Aug 24, 2012·Human Brain Mapping·Linda GeerligsMonicque M Lorist
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
Oct 16, 2013·Schizophrenia Bulletin·Nikolaos KoutsoulerisEva Meisenzahl
Jan 2, 2014·Frontiers in Aging Neuroscience·Katja FrankeVera Novak
Feb 18, 2014·Cerebral Cortex·Linda GeerligsMonicque M Lorist
Mar 7, 2014·Frontiers in Neuroinformatics·Alexandre AbrahamGaël Varoquaux
Aug 12, 2014·NeuroImage·Ricardo Pio MontiGiovanni Montana
Jan 28, 2015·Annals of Neurology·James H ColeUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda GeerligsRichard N Henson
Sep 8, 2016·Human Brain Mapping·Ricardo Pio MontiGiovanni Montana
Apr 5, 2017·Frontiers in Computational Neuroscience·Ricardo P MontiGiovanni Montana
Apr 26, 2017·Molecular Psychiatry·J H ColeI J Deary
Oct 28, 2017·Trends in Neurosciences·James H Cole, Katja Franke
Nov 21, 2017·PloS One·Henk R CremersTal Yarkoni
Mar 28, 2018·Nature Communications·Romy LorenzRobert Leech
Jun 26, 2018·ACS Applied Materials & Interfaces·C D GuJ P Tu
Jan 11, 2020·Frontiers in Aging Neuroscience·Natalia EgorovaAmy Brodtmann

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Citations

Mar 9, 2021·Frontiers in Psychiatry·Matthias S TrederKamen A Tsvetanov

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Methods Mentioned

BETA
PCA

Software Mentioned

R
MHA
Scikit Learn
SPM Dartel
FLIRT
nilearn
CamCAN
Python

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