Interpretation of 11C-choline PET/CT for the diagnosis of local relapse in radically treated prostate cancer

European Journal of Hybrid Imaging
A MattiC Nanni

Abstract

11C-choline PET/CT is a widely-used tool for the diagnostic of prostate cancer (PCa). In literature, a great variability of local relapse (LR) detection rate is reported. The aim of this study is to provide positivity criteria for 11C-choline PET/CT detection of LR in patients who had surgery for PCa and presented prostate specific antigen (PSA) failure. Sixty patients radically treated for PCa and presenting PSA failure were retrospectively analysed. Two Nuclear Medicine Physicians revised the 11C-choline PET/CT scans and defined by consensus if even mild focal uptake was present in the prostate bed (PB) and bladder-urethral junction (BUJ) along midline, regardless the previous report results.The results were subsequently correlated with a clinical and radiological follow up (FU) of 1 to 2 year and with TNM staging, Gleason score (GS), PSA level at relapse, radiotherapy (RT) and hormone therapy (HT) after surgery. There was focal uptake in 22/60 patients; 11 of them were true positive and 11 false positive. The PSA level showed a tight connection with the true positivity/negativity of Choline scan. Most of true positive cases (10/11 patients) presented a PSA ≥ 1 ng/ml, while approximately half of the false positive cases (5/11...Continue Reading

References

Sep 11, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Sven N ReskeGerhard Glatting
Sep 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·B J KrauseM Schwaiger
Apr 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Sebastian A MüllerReingard Senekowitsch-Schmidtke
Sep 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Giampiero GiovacchiniCristina Messa
Mar 15, 2013·Clinical Nuclear Medicine·Laura EvangelistaDomenico Rubello
Apr 18, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Cristina NanniStefano Fanti
Jun 18, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo CastellucciStefano Fanti

❮ Previous
Next ❯

Citations

Feb 23, 2020·Frontiers in Oncology·Anthony TurpinNicolas Penel

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging procedure
biopsies

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.