Interpretation of liver stiffness measurement-based approach for the monitoring of hepatitis B patients with antiviral therapy: A 2-year prospective study

Journal of Viral Hepatitis
X-E LiangJ Hou

Abstract

Liver biopsy is not routinely performed in treated chronic hepatitis B. Liver stiffness measurement has been validated for noninvasive liver fibrosis assessment in pretreatment chronic hepatitis B but has not been assessed for fibrosis monitoring during antiviral therapy. Liver stiffness was systemically monitored by Fibroscan® every 6 months in a cohort of patients with hepatitis B receiving antiviral therapy and compared with liver biopsies at baseline and week 104. A total of 534 hepatitis B e antigen-positive treatment-naive patients receiving telbivudine-based therapy with qualified liver stiffness measurement at baseline and week 104 were analyzed, 164 of which had adequate paired liver biopsies. Liver stiffness decreased rapidly (-2.2 kPa/24 weeks) in parallel with alanine aminotransferase (ALT) from 8.6 (2.6-49.5) kPa at baseline to 6.1 (2.2-37.4) kPa at week 24. Interestingly, liver stiffness decreased slowly (-0.3 kPa/24 weeks) but continually from week 24 to week 104 (6.1 vs 5.3 kPa, P < .001) while ALT levels remained stable within the normal range. More importantly, liver stiffness declined significantly irrespective of baseline ALT levels and liver necroinflammation grades. From baseline to week 104, the proportio...Continue Reading

References

Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
Jun 9, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Wai-Sun WongHenry Lik-Yuen Chan
Mar 31, 2011·Antiviral Therapy·Grace Lai-Hung WongHenry Lik-Yuen Chan
Jul 15, 2011·Alimentary Pharmacology & Therapeutics·C HézodeJ-M Pawlotsky
Sep 16, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiichi OgawaJun Hayashi
Jan 17, 2012·Journal of Hepatology·Elizabeth L Ellis, Derek A Mann
Nov 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Mi Na KimKwang-Hyub Han
Jan 3, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian SunJinlin Hou
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 23, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Pierre Bedossa
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado

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Citations

Oct 6, 2018·Journal of Gastroenterology and Hepatology·Xiao-Qin DongUNKNOWN China HepB-Related Fibrosis Assessment Research Group
Jan 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Grace Lai-Hung WongVincent Wai-Sun Wong
Mar 29, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Ming XiongJinlin Hou
Oct 28, 2019·Clinical and Translational Gastroenterology·Ming XiongJinlin Hou
Feb 19, 2020·Gut·Rohit Loomba, Leon A Adams
Jun 23, 2020·Chinese Medical Journal·Ya-Meng SunHong You
Nov 28, 2019·Journal of Clinical Medicine·Jeong-Ju YooSang Gyune Kim
Feb 29, 2020·Journal of Digestive Diseases·UNKNOWN Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association
Jan 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Zhong-Bin LiDong Ji
Jan 16, 2021·Journal of Clinical and Translational Hepatology·Hong Wei, Bin Song
Jul 29, 2021·World Journal of Gastrointestinal Pharmacology and Therapeutics·Niraj James ShahKumar Pallav

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