PMID: 11928764Apr 4, 2002Paper

Interpretation of plasma brain natriuretic peptide concentrations may require adjustment for patient's age

Annals of Clinical Biochemistry
Thuraia NagehRoy A Sherwood

Abstract

Brain natriuretic peptide (BNP) is increasingly recognized as a practical, reliable and accurate indicator of left ventricular function and may have an important prognostic role in determining outcome following myocardial infarction and heart failure. We studied a total of 60 patients referred for dobutamine-stress echocardiography to evaluate possible reversible myocardial ischaemia. There was no echocardiographic evidence of structural or functional heart disease in any of the patients included in the study. Blood was sampled for BNP at rest, prior to dobutamine-stress. We found a significant linear correlation between BNP concentrations and patients' age, in the absence of structural or functional heart disease (r(s) = 0.53, 95% CI 0.25-0.73, P<0.0001). Our observations suggest the need for consideration of patient's age when interpreting BNP concentrations in the population.

Citations

Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·David StejskalJosef Bartek
Oct 20, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Francesca Di SerioNicola Pansini
May 26, 2004·Clinics in Laboratory Medicine·William E Winter, Ronald J Elin
Oct 9, 2004·Clinical Cardiology·Daniel M Spevack, Arthur Schwartzbard
Nov 8, 2003·Critical Care Medicine·Evangelos Giannitsis, Hugo A Katus
Mar 26, 2005·American Journal of Reproductive Immunology : AJRI·Charles R WiraMargaret A Crane-Godreau

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