PMID: 3757399Oct 1, 1986Paper

Interpretation of traumatic lumbar puncture. A prospective experimental model

Clinical Pediatrics
A L Mehl

Abstract

Contamination of cerebrospinal fluid (CSF) with blood at the time of collection interferes with the interpretation of laboratory studies. Twenty-four children with normal CSF were studied prospectively using an experimental model. Blood was added to clear CSF, producing red cell counts from 1,000 to 600,000 cells per cubic millimeter. The expected values for white blood cell count, protein, percent neutrophils, and glucose were calculated, using the results from uncontaminated CSF, peripheral blood cell counts, blood protein, and the red blood cell count of the contaminated specimen. The ratio of observed values to expected values ranged from 0.13 to 3.00 for CSF white blood cell count (mean 0.96, standard deviation 0.56), from 0.55 to 1.63 for CSF protein (mean 0.97, standard deviation 0.23), and from 0.10 to 2.25 for percent neutrophils in the CSF (mean 1.17, standard deviation 0.41). CSF glucose was unchanged by the addition of blood. Guidelines for interpretation of laboratory studies following traumatic lumbar puncture are suggested.

References

May 1, 1981·Archives of Disease in Childhood·J P Osborne, B Pizer

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Citations

Jan 17, 2009·AJNR. American Journal of Neuroradiology·S D YuA J Johnson
Mar 24, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·T G GivensC M Walsh-Kelly
Apr 13, 2012·Diagnostic Microbiology and Infectious Disease·Kyle WhiteRobert Norton
Aug 31, 2010·The Journal of Pediatrics·Carrie L ByingtonXiaoming Sheng
May 31, 2011·Clinical Pediatrics·Miguel M GlatsteinShimon Reif
Jan 1, 1988·Clinical Pediatrics·R D Anbar
Sep 18, 2004·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·J M BoonT Welch
Jun 26, 2010·Pediatric Emergency Care·Dante Pappano
May 5, 2017·The Pediatric Infectious Disease Journal·Todd W LyonsUNKNOWN Herpes Simplex Virus Study Group of the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC)
Jul 17, 2003·Pediatric Case Reviews·David A Hunstad

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