Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Iren Yeeling WuMassimiliano Pio di Cagno

Abstract

The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two different model drugs (caffeine and hydrocortisone) formulated into liposomes through different types of barriers with different retention properties (regenerated cellulose and the newly introduced biomimetic barrier, Permeapad®). Drug release from liposomes was studied utilizing the standard Franz diffusion cells. LUV dispersions were exposed to the isotonic, hypotonic and hypertonic environment (difference of 300 mOsm/kg between the initial LUVs and the environment) and experimental data treated with both linear and non-linear (Korsmeyer-Peppas) regression models. To alter the rigidity of the liposomal membranes, cholesterol was introduced in the liposomal barriers (up to 25% w/w). Korsmeyer-Peppas model was proven to be suited to analyse experimental data throughout the experimental time frame, providing important additive information in comparison to standard linear approximation. The obtained results are highly relevant as they improve the interpretation of drug release kinetics from LUVs under osmotic stres...Continue Reading

Citations

Jun 4, 2020·Pharmaceutics·Elena Sánchez-LópezMaría José Gómara
Jun 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mateusz Pawlaczyk, Grzegorz Schroeder
May 13, 2020·Pharmaceutical Research·Ann-Christin JacobsenAnnette Bauer-Brandl
Dec 10, 2020·International Journal of Molecular Sciences·Shani L LevitChristina Tang
Nov 23, 2020·Food Chemistry·Rennan Felix da Silva BarbosaDerval Dos Santos Rosa
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Parvin Sadat MirzaghavamiVahid Pirhajati Mahabadi
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ameeduzzafar ZafarMohamed F Ibrahim
Jun 3, 2021·Marine Drugs·Lisa Myrseth HemmingsenNataša Škalko-Basnet
Jun 12, 2021·AAPS PharmSciTech·Zohreh Sadat Rastegar RamshehFarid Abedin Dorkoosh
Jun 22, 2021·Toxicology Reports·Angeliki LiakopoulouSophia Hatziantoniou

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