Interpreting REACH guidance in the determination of the derived no effect level (DNEL)

Regulatory Toxicology and Pharmacology : RTP
Marisa L Kreider, E Spencer Williams

Abstract

Under the new European chemicals regulation, REACH, a new safety value, the Derived No Effect Level (DNEL) must be established for all chemicals manufactured, imported or used in the EU in quantities greater than 10 metric tonnes per year. The DNEL is to be calculated for all relevant exposure pathways, exposure populations, and endpoints of toxicity. The EU has published guidance on how to derive the DNEL, but this guidance has yet to be put into practice and is in some places not prescriptive. Using the Agency for Toxic Substances and Disease Registry (ATSDR) dataset, we have determined inhalation DNELs for styrene. In doing so, we considered what effect key decisions would have on the calculated DNEL. The resulting DNELs were then compared to existing risk criteria values or occupational exposure limits. General population DNELs were generally more conservative than analogous risk criteria (ranging from approximately 0.05 to 2.5 ppm). Worker DNELs are lower than existing occupational standards (ranging from approximately 0.4 to 20 ppm). To our knowledge, this work represents the first rigorous application and interpretation of the EU guidance for determination of a DNEL and will prove useful as a model for determination of o...Continue Reading

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Citations

Jun 23, 2015·Journal of Occupational and Environmental Hygiene·M DeveauR W Niemeier
Dec 20, 2011·Regulatory Toxicology and Pharmacology : RTP·Peter J BoogaardGary D Minsavage
Nov 16, 2013·Regulatory Toxicology and Pharmacology : RTP·Dallas M CowanDennis J Paustenbach
Apr 13, 2013·Regulatory Toxicology and Pharmacology : RTP·Chris D MoneyR Jeffrey Lewis

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