Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels

The Journal of General Physiology
Altin Sula, B A Wallace

Abstract

Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential. In humans, mutations in sodium channels give rise to several neurological and cardiovascular diseases, and hence they are targets for pharmaceutical drug developments. Prokaryotic sodium channel crystal structures have provided detailed views of sodium channels, which by homology have suggested potentially important functionally related structural features in human sodium channels. A new crystal structure of a full-length prokaryotic channel, NavMs, in a conformation we proposed to represent the open, activated state, has revealed a novel interaction motif associated with channel opening. This motif is associated with disease when mutated in human sodium channels and plays an important and dynamic role in our new model for channel activation.

References

Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y QuW A Catterall
Dec 1, 1996·Journal of Molecular Graphics·O S SmartM S Sansom
Dec 18, 2001·Science·D RenD E Clapham
Dec 11, 2003·The Journal of Biological Chemistry·Ryuta KoishiDavid E Clapham
Jul 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masahiro ItoTerry A Krulwich
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Carlos A Villalba-GaleaFrancisco Bezanilla
Oct 22, 2008·Journal of Medical Genetics·C DepienneE LeGuern
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paul G DeCaenWilliam A Catterall
Feb 5, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jamie D KapplingerMichael J Ackerman
Jul 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew M PowlB A Wallace
Apr 5, 2011·Acta Crystallographica. Section D, Biological Crystallography·S McNicholasM E M Noble
Jul 12, 2011·Nature·Jian PayandehWilliam A Catterall
Jul 21, 2011·Biochemistry·Kalypso Charalambous, B A Wallace
Apr 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Martin B UlmschneiderB A Wallace
Sep 21, 2013·Nature Communications·Claire BagnérisB A Wallace
Mar 13, 2014·Nature Communications·Kevin OelstromBaron Chanda
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Claire BagnérisB A Wallace
Dec 18, 2015·Annals of Neurology·Elena GardellaYvonne G Weber
Dec 30, 2015·The Journal of General Physiology·Christopher A AhernBaron Chanda
Feb 14, 2016·The EMBO Journal·Claire E NaylorB A Wallace
Feb 17, 2017·Nature Communications·Altin SulaB A Wallace
Mar 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Michael J LenaeusWilliam A Catterall

❮ Previous
Next ❯

Citations

Feb 21, 2019·Physical Chemistry Chemical Physics : PCCP·Rudramani PokhrelPrem P Chapagain
Jun 1, 2019·Chembiochem : a European Journal of Chemical Biology·Karli LipinskiDenise V Greathouse
Dec 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Geancarlo ZanattaB A Wallace
Oct 23, 2020·ELife·Lily Goodyer SaitB A Wallace
Feb 16, 2018·Biochimica Et Biophysica Acta. Biomembranes·Matthew J McKayDenise V Greathouse
Dec 17, 2021·Plant Signaling & Behavior·François BouteauPatrick Laurenti

❮ Previous
Next ❯

Methods Mentioned

BETA
circular dichroism

Software Mentioned

CavAb
CCP4Mg
HOLE

Related Concepts

Related Feeds

Bacterial Protein Structures (ASM)

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

© 2022 Meta ULC. All rights reserved