Interpreting variability in population biomonitoring data: role of elimination kinetics

Journal of Exposure Science & Environmental Epidemiology
Lesa L AylwardSean M Hays

Abstract

Biomarker concentrations in spot samples of blood and urine are implicitly interpreted as direct surrogates for long-term exposure magnitude in a variety of contexts including (1) epidemiological studies of potential health outcomes associated with general population chemical exposure, and (2) cross-sectional population biomonitoring studies. However, numerous factors in addition to exposure magnitude influence biomarker concentrations in spot samples, including temporal variation in spot samples because of elimination kinetics. The influence of half-life of elimination relative to exposure interval is examined here using simple first-order pharmacokinetic simulations of urinary concentrations in spot samples collected at random times relative to exposure events. Repeated exposures were modeled for each individual in the simulation with exposure amounts drawn from lognormal distributions with varying geometric standard deviations. Relative variation in predicted spot sample concentrations was greater than the variation in underlying dose distributions when the half-life of elimination was shorter than the interval between exposures, with the degree of relative variation increasing as the ratio of half-life to exposure interval ...Continue Reading

References

Oct 1, 1990·Journal of the Air & Waste Management Association·W R Ott
Mar 1, 1996·Journal of Toxicology and Environmental Health·D Flesch-JanysO Päpke
Nov 30, 2000·Environmental Health Perspectives·M C KohnL L Needham
May 11, 2002·Environmental Health Perspectives·Jane A HoppinDonna D Baird
Jun 10, 2004·Journal of Exposure Analysis and Environmental Epidemiology·John C KisselRichard A Fenske
Sep 2, 2004·Journal of Exposure Analysis and Environmental Epidemiology·John D MeekerRuss Hauser
Dec 8, 2004·Environmental Health Perspectives·Russ HauserAntonia M Calafat
Mar 4, 2005·Environmental Health Perspectives·Ken SextonAndrew D Ryan
Jun 22, 2006·Journal of Exposure Science & Environmental Epidemiology·Deanna P ScherKathy A Brzak
Sep 6, 2006·Journal of Toxicology and Environmental Health. Part a·Gunilla Sandborgh-EnglundJan Ekstrand
Dec 22, 2006·International Journal of Hygiene and Environmental Health·Hermann FrommeBernhard Liebl
Feb 22, 2008·Environmental Health Perspectives·Shruthi MahalingaiahRuss Hauser
Apr 17, 2008·Journal of Exposure Science & Environmental Epidemiology·Matthew Lorber
Apr 17, 2008·Environmental Health Perspectives·Jennifer J AdibiRuss Hauser
Jun 27, 2008·Regulatory Toxicology and Pharmacology : RTP·Lesa L AylwardSean M Hays
Jun 28, 2008·Regulatory Toxicology and Pharmacology : RTP·Sean M Hays, Lesa L Aylward
Jul 1, 2008·Toxicology and Applied Pharmacology·Harvey J ClewellMelvin E Andersen
Feb 19, 2009·Journal of Exposure Science & Environmental Epidemiology·Jennifer David PeckSusan L Schantz
Mar 12, 2009·Journal of Exposure Science & Environmental Epidemiology·Donna Day BairdAllen J Wilcox
Apr 2, 2009·Environmental Health Perspectives·Molly L KileDavid C Christiani
Mar 20, 2010·Journal of Exposure Science & Environmental Epidemiology·Judy S Lakind, Daniel Q Naiman
Apr 30, 2010·International Journal of Hygiene and Environmental Health·Zorimar Rivera-NúñezJerome O Nriagu
Jun 22, 2010·Molecular Nutrition & Food Research·Matthias WittassekThomas Brüning
Jul 6, 2010·Toxicology Letters·Suzanne SpaanErik Tielemans
Jan 6, 2011·Environmental Health Perspectives·Joe M BraunBruce P Lanphear
Mar 17, 2011·Environmental Health Perspectives·Xiaoyun YeAntonia M Calafat
Jan 1, 2004·Environmental Health and Preventive Medicine·Chikako ArakawaHiroaki Shiraishi
Jun 28, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Justin G TeeguardenMorgan K Graham

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Citations

Aug 29, 2013·Journal of Toxicology and Environmental Health. Part a·Joachim D Pleil, Jon R Sobus
Oct 17, 2015·Regulatory Toxicology and Pharmacology : RTP·Claire TerryDaland R Juberg
Oct 10, 2015·Regulatory Toxicology and Pharmacology : RTP·Lesa L AylwardSean M Hays
Nov 8, 2015·Regulatory Toxicology and Pharmacology : RTP·Kathleen BrownYu-Mei Tan
Jan 7, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Richard A BeckerKimberly Wise
Mar 15, 2016·Regulatory Toxicology and Pharmacology : RTP·Sean M HaysLesa L Aylward
Oct 18, 2015·International Journal of Hygiene and Environmental Health·Torka PoetSean M Hays
Oct 30, 2014·Journal of Exposure Science & Environmental Epidemiology·Christiaan DelmaarGerlienke Schuur
Apr 12, 2015·Regulatory Toxicology and Pharmacology : RTP·L L AylwardA Nong
Sep 29, 2012·Regulatory Toxicology and Pharmacology : RTP·Sean M HaysChristopher Kirman
Sep 15, 2014·The Science of the Total Environment·Gurusankar SaravanabhavanLesa Aylward
Apr 15, 2014·Environment International·Amy L HeffernanJ F Mueller
May 13, 2014·Regulatory Toxicology and Pharmacology : RTP·Krista L Y ChristensenMatthew Lorber
May 23, 2014·Regulatory Toxicology and Pharmacology : RTP·Martin B PhillipsYu-Mei Tan
Apr 23, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·L L AylwardR A Becker
Mar 7, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Lesa L AylwardRuth Bevan
Aug 2, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Joachim D PleilWilliam E Funk
Sep 25, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alice A HanJordan N Smith
Aug 12, 2018·Pharmaceutics·Zhi-Yuan ZhangGuo-Liang Zhang
Sep 22, 2017·Chemical Research in Toxicology·Gabriele Sabbioni
Dec 24, 2019·Environmental Science & Technology·David L AshleyBenjamin C Blount
Dec 6, 2018·Environmental Science & Technology·Caroline L RingJohn F Wambaugh
Aug 14, 2020·Environmental Science & Technology·Jacob KvasnickaMiriam L Diamond
Jul 17, 2020·Chemical Research in Toxicology·Gabriele SabbioniBilly W Day

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