Interpretive criteria for antimicrobial susceptibility testing of ceftiofur against bacteria associated with swine respiratory disease

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
P J BurtonR J Yancey

Abstract

Ceftiofur, an extended-spectrum cephalosporin, is active against a variety of animal pathogens, including organisms associated with swine respiratory disease. However, minimum inhibitory concentration (MIC) breakpoint and disk diffusion interpretive criteria have not been established for swine pathogens. Susceptibility tests were performed by broth microdilution MIC and disk diffusion methods on 246 bacterial species that cause swine respiratory disease. Ceftiofur was active against Salmonella sp., Pasteurella multocida, Actinobacillus pleuropneumoniae, Streptococcus suis, and Escherichia coli but was not active against Bordetella bronchiseptica measured by MIC. Based on pharmacokinetic studies of ceftiofur in swine after a single intramuscular injection of 3 or 5 mg/kg body weight of ceftiofur and on the MIC and disk diffusion data, we recommend MIC breakpoints and disk diffusion distances, respectively, of < or = 2 micrograms/ml and > or = 21 mm for susceptible, 4 micrograms/ml and 18-20 mm for intermediate, and > or = 8 micrograms/ml and > or = 17 mm for resistant classification for swine pathogens. When these breakpoints were applied to data from a previous study using bovine pathogens, only 1 minor interpretive error occur...Continue Reading

References

Jul 1, 1992·Equine Veterinary Journal·S D FolzJ H Foreman
Dec 1, 1974·The Journal of Infectious Diseases·C M Metzler, R M DeHaan

❮ Previous
Next ❯

Citations

Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Kristina KadlecStefan Schwarz
Apr 21, 2012·Emerging Infectious Diseases·Daniel A TadessePatrick F McDermott
Apr 26, 2014·American Journal of Veterinary Research·Hyeun Bum KimRichard E Isaacson
Mar 3, 2010·International Immunopharmacology·Xiao ChuXuming Deng
May 14, 2008·Biochemical and Biophysical Research Communications·Xinxin CiXuming Deng
Aug 10, 2007·Veterinary Microbiology·Stefan SchwarzChristiane Werckenthin
Jan 30, 2004·Letters in Applied Microbiology·K M BischoffD J Nisbet
Feb 18, 2015·Veterinary Research Communications·Chrząstek Klaudia, Wieliczko Alina
Feb 2, 2010·The Veterinary Clinics of North America. Food Animal Practice·Jeffrey L Watts, Michael T Sweeney
Dec 29, 2016·American Journal of Veterinary Research·Scott H EdwardsSharanne L Raidal
Jan 31, 2007·The Journal of Antimicrobial Chemotherapy·Kristina KadlecStefan Schwarz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
S A SalmonR J Yancey
Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
M Tanigawa, T Sawada
The Veterinary Record
M L Seddon, S J Barry
© 2021 Meta ULC. All rights reserved