Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97.

Proceedings of the National Academy of Sciences of the United States of America
Guangtao LiWilliam J Lennarz

Abstract

Multimeric AAA ATPases represent a structurally homologous yet functionally diverse family of proteins. The essential and highly abundant hexameric AAA ATPase p97 is perhaps the best studied AAA protein, playing an essential role in various important cellular activities. During ATP-hydrolysis process, p97 undergoes dramatic conformational changes, and these changes are initiated in the C-terminal ATPase domain and transmitted across the entire length of the molecule to the N-terminal effector domain. However, the detailed mechanism of the motion transmission remains unclear. Here, we report an interprotomer motion-transmission mechanism to explain this process: The nucleotide-dependent motion transmission between the two ATPase domains of one protomer is mediated by its neighboring protomer. This finding reveals a strict requirement for interprotomer coordination of p97 during the motion-transmission process and may shed light on studies of other AAA ATPases.

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Citations

Jun 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chengdong HuangWilliam J Lennarz
Feb 18, 2014·Acta Crystallographica. Section D, Biological Crystallography·Cathleen ZeymerJochen Reinstein
Mar 7, 2014·Open Biology·Heidi O YeungPaul S Freemont
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Sep 1, 2015·FEBS Letters·Alexander BuchbergerPetra Hänzelmann
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Nov 27, 2015·Journal of Molecular Biology·Dominik Barthelme, Robert T Sauer
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyi ZhangTsui-Fen Chou
Feb 19, 2015·Journal of Biomolecular Screening·Michael S ChimentiMark J S Kelly
Nov 11, 2019·Biomolecules·Michael PrattesRobin E Stanley
Apr 19, 2013·The Journal of Biological Chemistry·Jing LiuNing Gao
Apr 30, 2017·Frontiers in Molecular Biosciences·Petra Hänzelmann, Hermann Schindelin
May 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Emily E BlytheRaymond J Deshaies
Apr 27, 2016·Chembiochem : a European Journal of Chemical Biology·Taehyung C LeeAshok A Deniz
Aug 19, 2021·The Biochemical Journal·Xiaoyi ZhangTsui-Fen Chou

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