Abstract
Inappropriate aldosterone and parathyroid hormone (PTH) secretion is associated with increased cardiovascular risk. Accumulating evidence suggests bidirectional interplay between aldosterone and PTH. We evaluated the cross-sectional relationship between plasma aldosterone concentration (PAC), aldosterone to renin ratio (ARR) and PTH and subsequently tested whether the interaction between PAC and PTH modified the risk of cardiovascular death. PAC [78.0 (48.0-123.0) pg/mL], ARR [6.4 (2.9-12.9) pg/mL/pg/mL] and PTH concentration [median: 29.0 (22.0-40.0) pg/mL] were measured in 3074 patients (mean age: 62.5 ± 10.6 years; 30.3% women) referred to coronary angiography in a tertiary care center in Southwest Germany. Using multiple linear regression analysis, PAC and ARR emerged as an independent predictor of higher PTH concentrations (β=0.12 and 0.21, P<0.001 for both) irrespective of intake of antihypertensive treatment, 25(OH)D, kidney function, serum calcium, phosphate, magnesium, cortisol, NT-pro-BNP, soluble α-klotho and FGF-23 concentration. After a median follow-up of 9.9 years, 512 (16.7%) participants had died due to fatal cardiovascular events. Multivariate Cox proportional hazard analysis revealed that both PAC and PTH wer...Continue Reading
References
Jul 1, 1991·Endocrinology·C M IsalesH Rasmussen
Sep 1, 1987·Calcified Tissue International·R PacificiL V Avioli
Aug 1, 1993·Endocrinology·P UreñaG V Segre
Jun 13, 1998·European Journal of Endocrinology·L KovácsG Szilágyi
Aug 6, 1999·Clinical Endocrinology·A PiovesanG Borretta
Mar 22, 2001·Pharmacogenomics·B R WinkelmannUNKNOWN LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health)
Apr 3, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S TrenkelJ Hensen
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Vikram S ChhokarKarl T Weber
Feb 16, 2005·Circulation·Vikram S ChhokarKarl T Weber
Jul 5, 2005·Journal of the American College of Cardiology·Peter H LawKarl T Weber
Jul 16, 2005·The American Journal of the Medical Sciences·Aliye L RunyanKarl T Weber
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan FuentesDeborah M Power
Feb 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Shonni J SilverbergMishaela R Rubin
Apr 9, 2009·BMC Endocrine Disorders·Stefan PilzThomas R Pieber
Jan 21, 2010·Statistics in Medicine·Loic Desquilbet, François Mariotti
Mar 5, 2010·European Heart Journal·Andreas TomaschitzWinfried März
Mar 13, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Tomaschitz, S Pilz
May 5, 2010·European Heart Journal·Stefan PilzWinfried März
Dec 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andreas TomaschitzWinfried März
Aug 10, 2011·Hypertension·Carmela ManieroGian Paolo Rossi
Aug 23, 2011·European Heart Journal·Frank EdelmannBurkert Pieske
Oct 21, 2011·The Journal of Clinical Endocrinology and Metabolism·Stefan PilzAndreas Tomaschitz
Feb 16, 2012·Cardiovascular Research·Andreas TomaschitzStefan Pilz
Sep 15, 2012·BMC Endocrine Disorders·Andreas TomaschitzStefan Pilz
Jan 10, 2013·The Journal of Clinical Investigation·Jakob VoelklFlorian Lang
Oct 8, 2013·Metabolism: Clinical and Experimental·Andreas TomaschitzStefan Pilz
Nov 6, 2013·Hypertension·Jenifer M BrownAnand Vaidya
Nov 6, 2013·Hypertension·Andreas Tomaschitz, Stefan Pilz
Apr 4, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Jenifer M Brown, Anand Vaidya
Jul 9, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mona HassanZaid Alirhayim
Sep 10, 2014·Atherosclerosis·Vincent M BrandenburgHubert Scharnagl
Citations
Apr 9, 2016·International Journal of Cardiology·Damien GrusonMichel F Rousseau
Oct 13, 2015·The Journal of Clinical Hypertension·Nicolas D VerheyenStefan Pilz
Jan 8, 2017·Clinical and Experimental Nephrology·Hideki Fujii, Nobuhiko Joki
Jul 6, 2016·Journal of Hypertension·Nicolas VerheyenAndreas Tomaschitz
May 8, 2018·Clinical Endocrinology·Lise Sofie BislevLars Rejnmark
Dec 22, 2017·BMC Nephrology·Christina M GantUNKNOWN Holland Nephrology Study (HONEST) Network
Dec 5, 2018·Endocrinology and Metabolism·Jung Soo LimYumie Rhee
Dec 25, 2017·BMJ Case Reports·Kristen Elizabeth DeCarlo, Nidhi Agrawal
Jun 25, 2020·ESC Heart Failure·Clotilde RoyAnne-Catherine Pouleur
Sep 12, 2020·Lupus Science & Medicine·Mayra GiannelouClio P Mavragani
Apr 12, 2016·Journal of Hypertension·Andreas TomaschitzStefan Pilz
May 1, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hideki Fujii
Aug 16, 2017·International Journal of Endocrinology·Sarah ZaheerAnand Vaidya
Sep 14, 2020·Journal of Bone and Mineral Metabolism·Keiji KonoShinichi Nishi
Dec 22, 2020·Terapevticheskiĭ arkhiv·E A DobrevaN G Mokrysheva