Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular mortality risk

International Journal of Cardiology
Andreas TomaschitzWinfried März

Abstract

Inappropriate aldosterone and parathyroid hormone (PTH) secretion is associated with increased cardiovascular risk. Accumulating evidence suggests bidirectional interplay between aldosterone and PTH. We evaluated the cross-sectional relationship between plasma aldosterone concentration (PAC), aldosterone to renin ratio (ARR) and PTH and subsequently tested whether the interaction between PAC and PTH modified the risk of cardiovascular death. PAC [78.0 (48.0-123.0) pg/mL], ARR [6.4 (2.9-12.9) pg/mL/pg/mL] and PTH concentration [median: 29.0 (22.0-40.0) pg/mL] were measured in 3074 patients (mean age: 62.5 ± 10.6 years; 30.3% women) referred to coronary angiography in a tertiary care center in Southwest Germany. Using multiple linear regression analysis, PAC and ARR emerged as an independent predictor of higher PTH concentrations (β=0.12 and 0.21, P<0.001 for both) irrespective of intake of antihypertensive treatment, 25(OH)D, kidney function, serum calcium, phosphate, magnesium, cortisol, NT-pro-BNP, soluble α-klotho and FGF-23 concentration. After a median follow-up of 9.9 years, 512 (16.7%) participants had died due to fatal cardiovascular events. Multivariate Cox proportional hazard analysis revealed that both PAC and PTH wer...Continue Reading

References

Sep 1, 1987·Calcified Tissue International·R PacificiL V Avioli
Mar 22, 2001·Pharmacogenomics·B R WinkelmannUNKNOWN LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health)
Apr 3, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S TrenkelJ Hensen
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Vikram S ChhokarKarl T Weber
Feb 16, 2005·Circulation·Vikram S ChhokarKarl T Weber
Jul 5, 2005·Journal of the American College of Cardiology·Peter H LawKarl T Weber
Jul 16, 2005·The American Journal of the Medical Sciences·Aliye L RunyanKarl T Weber
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan FuentesDeborah M Power
Feb 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Shonni J SilverbergMishaela R Rubin
Jan 21, 2010·Statistics in Medicine·Loic Desquilbet, François Mariotti
Mar 13, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Tomaschitz, S Pilz
Dec 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andreas TomaschitzWinfried März
Aug 10, 2011·Hypertension·Carmela ManieroGian Paolo Rossi
Oct 21, 2011·The Journal of Clinical Endocrinology and Metabolism·Stefan PilzAndreas Tomaschitz
Feb 16, 2012·Cardiovascular Research·Andreas TomaschitzStefan Pilz
Jan 10, 2013·The Journal of Clinical Investigation·Jakob VoelklFlorian Lang
Oct 8, 2013·Metabolism: Clinical and Experimental·Andreas TomaschitzStefan Pilz
Apr 4, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Jenifer M Brown, Anand Vaidya
Jul 9, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mona HassanZaid Alirhayim

❮ Previous
Next ❯

Citations

Apr 9, 2016·International Journal of Cardiology·Damien GrusonMichel F Rousseau
Jan 8, 2017·Clinical and Experimental Nephrology·Hideki Fujii, Nobuhiko Joki
Dec 22, 2017·BMC Nephrology·Christina M GantUNKNOWN Holland Nephrology Study (HONEST) Network
Dec 5, 2018·Endocrinology and Metabolism·Jung Soo LimYumie Rhee
Dec 25, 2017·BMJ Case Reports·Kristen Elizabeth DeCarlo, Nidhi Agrawal
Sep 12, 2020·Lupus Science & Medicine·Mayra GiannelouClio P Mavragani
May 1, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hideki Fujii
Aug 16, 2017·International Journal of Endocrinology·Sarah ZaheerAnand Vaidya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.