PMID: 108352Mar 1, 1979

Interrelation of the pituitary-thyroid system at birth in man

The Journal of Endocrinology
P G ByfieldR L Himsworth

Abstract

Samples of cord blood derived from 105 normal babies after uncomplicated deliveries were assayed for thyroxine (T4), tri-iodothyronine (T3), reverse tri-iodothyronine (rT3), thyroxine-binding globulin (TBG) and thyrotrophin (TSH). The values for T3, rT3 and TSH were log-normally distributed (geometric means 0.62 nmol/l, 3.28 nmol/l and 10.9 mu./l respectively) and those for T4 and TBG were normally distributed (means 126 nmol/l and 13.7 mg/l), The data were systematically analysed and no evidence was obtained to suggest that the concentration of TSH, which varied widely, was regulated by any of the thyroid hormones alone or in combination. There was a direct relation between the concentrations of T4 and T3 in the cord blood at birth but not between either of these and rT3. There is thus no evidence of a functional interdependence of the hypothalamic-pituitary-thyroid system in man at birth.

Citations

Oct 1, 1989·British Journal of Obstetrics and Gynaecology·T T Lao, N S Panesar
Jul 1, 1981·Clinical Endocrinology·C J PearceR L Himsworth
Jun 1, 1982·Clinical Endocrinology·M J FarthingA M Dawson
Oct 1, 1984·Clinical Endocrinology·M R LallozR L Himsworth
Dec 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·J F DeakinP Lawler

Related Concepts

Umbilical Cord Blood
Pituitary Stalk
Thyroid Gland
Thyrotropin
Novothyral
Thyroxine-Binding Proteins
Cytomel
Reverse Triiodothyronine

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