PMID: 9535052Apr 16, 1998Paper

Interrelations between hypothalamic somatostatin and proopiomelanocortin neurons

Journal of Neuroendocrinology
M FodorS Jégou

Abstract

Somatostatin receptors were visualized by [125I]-Tyr0-DTrp8-somatostatin radioautography on 35% of arcuate neurons containing proopiomelanocortin (POMC) mRNA, as identified by in situ hybridization using a [35S] labelled riboprobe on 5 microm-thick consecutive sections. Furthermore, double immunohistochemical staining revealed contacts of beta-endorphin or alpha-MSH containing fibres with a majority of somatostatin perikarya in the anterior hypothalamic periventricular nucleus. Taken together, these data indicate that hypothalamic somatostatin and POMC neurons are interconnected. The results are discussed in term of intrahypothalamic control of GH secretion.

References

Nov 25, 1985·FEBS Letters·J DrouinM Nemer
May 1, 1988·Neuroendocrinology·S DaikokuK Chihara
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·H TostivintH Vaudry

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Citations

Apr 15, 2015·Frontiers in Neuroanatomy·Daqing WangCheng Zhan
Dec 14, 2001·Neuroreport·M Fodor, H A Delemarre-van de Waal
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kate L J Ellacott, Roger D Cone
Apr 27, 2016·The Journal of Comparative Neurology·Rajae TalbiValérie Simonneaux

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