Interrelationship Between Alcohol Intake and Endogenous Sex-Steroid Hormones on Diabetes Risk in Postmenopausal Women

Journal of the American College of Nutrition
Rachelle D RohwerYiqing Song

Abstract

We examined whether circulating concentrations of sex hormones, including estradiol, testosterone, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS), were associated with alcohol intake or mediated the alcohol-type 2 diabetes (T2D) association. Among women not using hormone replacement therapy and free of baseline cardiovascular disease, cancer, and diabetes in the Women's Health Study, 359 incident cases of T2D and 359 matched controls were chosen during 10 years of follow-up. Frequent alcohol intake (≥1 drink/day) was positively and significantly associated with higher plasma estradiol concentrations in an age-adjusted model (β = 0.14, 95% confidence interval [CI], 0.03, 0.26), compared to rarely/never alcohol intake. After adjusting for additional known covariates, this alcohol-estradiol association remained significant (β = 0.19, 95% CI, 0.07, 0.30). Testosterone (β = 0.13, 95% CI, -0.05, 0.31), SHBG (β = 0.07, 95% CI, -0.07, 0.20), and DHEAS (β = 0.14, 95% CI, -0.04, 0.31) showed positive associations without statistical significance. Estradiol alone or in combination with SHBG appeared to influence the observed protective association between frequent alcohol consumption and T2D risk, with a 1...Continue Reading

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Citations

Nov 6, 2017·Current Diabetes Reports·Sarit Polsky, Halis K Akturk
May 10, 2016·Endocrine Reviews·Alexandra Kautzky-WillerGiovanni Pacini
Oct 28, 2019·Drug Metabolism Reviews·Brendan Le DaréThomas Gicquel
May 25, 2021·The Ocular Surface·Morten Schjerven MagnoJelle Vehof

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Methods Mentioned

BETA
hormone replacement therapy
blood draw

Software Mentioned

GraphPad
GraphPad Prism
SAS

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