PMID: 2496762May 15, 1989Paper

Interrelationship between Ca2+-dependent phospholipid base-exchange reaction and phospholipase D-like activity in bovine retina

Biochimica Et Biophysica Acta
H MoriK Hosaka

Abstract

Endogenous substrates (phosphatidylserine, phosphatidylethanolamine and phosphatidylcholine) for the Ca2+-dependent base-exchange reaction were investigated using bovine retinal microsomes. The amounts of the three bases, serine, ethanolamine and choline, released from the membranes and the amount of phosphatidic acid generated in the membranes were measured in the presence of Ca2+ with or without exogenous bases. When the membranes were incubated with Ca2+ alone, the three bases were liberated into the water-soluble fractions accompanied by accumulation of phosphatidic acid, suggesting the presence of Ca2+-dependent phospholipase D-like activity. When an exogenous base was added to the reaction mixture, the liberation of the other two bases increased slightly and the formation of phosphatidic acid decreased markedly. The exogenous base also stimulated the liberation of the same base from prelabeled phospholipids. Accompanying these changes, the exogenous base was incorporated into the membrane phospholipid. With respect to pH profile, time course and metal requirements, both the base incorporation and phospholipase D-like activity were quite similar. The amount of base incorporated generally agreed with both the decreased amou...Continue Reading

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Citations

Sep 22, 1993·Molecular and Cellular Biochemistry·R MozziL A Horrocks
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·Z Y HuP G Rhodes
Oct 1, 1991·Bioscience Reports·J ZborowskiG Arienti
Jan 1, 1991·Life Sciences·S D Shukla, S P Halenda

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