PMID: 3754782Apr 16, 1986Paper

Interrelationship between central bradykinin and vasopressin in conscious rats

Brain Research
D P BrooksA Nasjletti

Abstract

Intracerebroventricular administration of bradykinin (1, 5 and 20 micrograms) into conscious rats resulted in significant dose-dependent increases in the plasma vasopressin concentration, mean arterial blood pressure and heart rate. Peripheral blockade of the pressor action of vasopressin with a vasopressin pressor antagonist (10 micrograms/kg, i.v.) did not cause an attenuation but rather a potentiation and prolongation of the pressor effects of central bradykinin (20 micrograms). Central administration of the vasopressin antagonist (150 ng) caused no peripheral blockade of the pressor effects of exogenous i.v. vasopressin but almost abolished the bradykinin-induced tachycardia, with little effect on the pressor effects of central bradykinin (20 micrograms). The results indicate that centrally administered bradykinin stimulates vasopressin release into the plasma and that central vasopressin may modulate the cardiovascular actions of central bradykinin.

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Citations

Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Jan 10, 1998·British Journal of Pharmacology·A DendorferP Dominiak
Jun 11, 1999·Japanese Journal of Pharmacology·A DendorferP Dominiak
Oct 12, 2007·Physiological Reviews·Robert A Fenton, Mark A Knepper
May 25, 2002·Canadian Journal of Physiology and Pharmacology·F QadriP Dominiak

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