PMID: 2484414Dec 1, 1989Paper

Interrelationship between iron deficiency and lead intoxication (Part 1)

Biological Trace Element Research
N S HashmiS K Tandon

Abstract

The influence of lead exposure, iron deficiency, or their combination on certain biochemical parameters in blood, plasma, and urine of rats was investigated in an attempt to identify the specific diagnostic tests of the two conditions and to draw a possible interrelationship between the two factors. The decrease in blood-glutathione peroxidase activity, -packed cell volume, plasma-ceruloplasmin, and-Fe levels and increase in urinary excretion of delta-aminolevulinic acid, plasma-cholesterol, and-total Fe binding capacity occur under Fe deficiency as well as Pb intoxication. However, increase in the activity of blood delta-aminolevulinic acid dehydratase (ALAD) without any change in blood zinc protoporphyrin (ZPP) level appears to be a specific effect of Fe deficiency that could be distinguished from Pb intoxication, a condition characterized by the inhibition in blood ALAD activity accompanied by an increase in blood ZPP level. The linear regression analysis of the data showed that the blood Pb and plasma free cholesterol levels increase with the decrease in plasma Fe level.

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Citations

Sep 1, 1992·Biological Trace Element Research·H DhirG Talukder
Jun 6, 1994·The Science of the Total Environment·S K TandonN Mathur
Sep 29, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A WalterJ Pallauf
Dec 4, 2002·Environmental Health Perspectives·Lisa GallicchioMary Sexton
Dec 1, 1989·Biological Trace Element Research·N S HashmiS K Tandon
Jul 27, 2011·Environmental Toxicology and Pharmacology·Rafał PorębaRyszard Andrzejak
Jun 6, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Hoda Yahya TomoumSamah Mohammed Ahmed
Aug 25, 2004·The Science of the Total Environment·Wilson T KwongRichard D Semba
Jan 1, 1995·European Journal of Clinical Investigation·G ChalevelakisS Raptis
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·T KákosyM Náray

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