Interrelationship of sildenafil treatment effects on the physiological and psychosocial aspects of erectile dysfunction of mixed or organic etiology

The Journal of Sexual Medicine
Stanley E AlthofGabriel Schnetzler

Abstract

In a previous paper using mediation modeling, the direct and indirect effects of sildenafil on erection maintenance were demonstrated. In an extension of this previous work, the historical psychosocial paradigm of ED, which focuses on performance anxiety, is tested by using mediation modeling to define the relationship of the physiological aspects (hardness and maintenance) and the associated psychosocial aspects (confidence, sexual relationship satisfaction, and performance anxiety) of ED. Statistical mediation analysis using the following outcomes from a double-blind placebo-controlled trial of fixed-dose sildenafil 100 mg or 50 mg: Erection Hardness Score; the 15-item International Index of Erectile Function (IIEF), including item 4 (frequency of erection maintenance after penetration) and item 5 (difficulty of erection maintenance to intercourse completion); the Self-Esteem And Relationship questionnaire; and the question, "Do you feel anxious about your next attempt at sexual intercourse?" Estimated percentages of direct and indirect effects of sildenafil on psychosocial aspects of ED (95% confidence intervals). The model estimated that erection hardness mediated 43.7% (29.3%, 62.4%) of the effect of treatment onto confide...Continue Reading

References

Aug 2, 2002·International Journal of Impotence Research·R C RosenN Gendrano
Jun 26, 2003·International Journal of Impotence Research·F Hedon
Feb 14, 2004·International Journal of Impotence Research·J C CappelleriS Duttagupta
Jan 21, 2006·The Journal of Sexual Medicine·Dimitrios HatzichristouUNKNOWN Vardenafil Study Group
Mar 21, 2007·The Journal of Sexual Medicine·Antonio Martin-MoralesAna Muñoz
Jan 16, 2009·The Journal of Sexual Medicine·Joseph C CappelleriGabriel Schnetzler

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Citations

Jan 24, 2014·International Journal of Impotence Research·W-K Tsai, B-P Jiann
Sep 3, 2011·The Journal of Sexual Medicine·Gudrun SchneiderMichael Zitzmann
Jan 10, 2012·The Journal of Sexual Medicine·Emmanuele A JanniniGerald B Brock
Oct 31, 2012·BJU International·Jae Sang ByunChong Won Bak
Feb 22, 2013·Statistical Methods in Medical Research·Joseph C Cappelleri, Andrew G Bushmakin
Mar 7, 2019·International Journal of Impotence Research·Nickolas D ScherzerWayne J G Hellstrom
Jul 23, 2020·European Journal of Internal Medicine·Athanasios ManolisGiuseppe Mancia

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