Interrelationship of the distribution of neuropeptides and tyrosine hydroxylase immunoreactivity in the human substantia Nigra.

The Journal of Comparative Neurology
S Haber, H J Groenewegen

Abstract

The relationship in the human substantia nigra of peptidergic fibers with intrinsic dopaminergic neurons was studied in adjacent coronal sections of the mesencephalon immunohistochemically stained for enkephalin (ENK), substance P (SP), and tyrosine (TH) hydroxylase immunoreactivity. TH-positive elements are present in the substantia nigra in at least two different arrangements: 1) a dorsal tier of rather loosely arranged neurons, which is continuous medially with the ventral tegmental area and laterally with the retrorubral area, 2) a ventral tier of more closely packed neurons, clusters of which frequently form finger-like extensions deep into the pars reticulata. This ventral region contains TH-positive dendrites extending ventrally into the pars reticulata. The distribution of ENK is mainly restricted to the medial half of the ventral aspect of the substantia nigra, while SP occupies its entire rostral-caudal and medial-lateral extents. Peptide-positive fibers vary in density from dense to light. There is very little overlap between the dorsal tier of the TH-positive neurons and the ENK or SP staining. The dorsal part of the peptide-immunoreactive area extensively overlaps with the TH-positive neurons of the ventral tier of...Continue Reading

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Citations

Jan 1, 1995·Brain Research. Brain Research Reviews·A Parent, L N Hazrati
Jun 1, 1992·Brain Research. Molecular Brain Research·A M EdelmanJ Cho-Lee
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Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Marianne Vázquez-ClaverieMaría Rosario Luquin
Oct 14, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane LehéricyChantal François
Mar 3, 1997·The Journal of Comparative Neurology·I AubertB Bloch
Mar 24, 2020·Brain : a Journal of Neurology·Yaping ChuJeffrey H Kordower
Mar 1, 1993·The Journal of Comparative Neurology·S N HaberS J Mitchell
Jul 22, 1994·The Journal of Comparative Neurology·E Lynd-Balta, S N Haber
Jun 15, 1993·The Journal of Comparative Neurology·C L LiangD C German

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