Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity

The EMBO Journal
Meghan S Soustek, Pere Puigserver

Abstract

Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis,non-alcoholic fatty liver, and cancer. In this issue of The EMBO Journal,Fujita et al (2015) describe the role of an endoplasmic reticulum (ER)-resident E3ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC-1b, a transcriptional modulator of mitochondrial oxidative metabolism.

References

Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Feb 1, 2008·Nature Clinical Practice. Rheumatology·Naoko YagishitaToshihiro Nakajima
Aug 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Neeraj K SharmaSteven C Elbein
Jun 2, 2010·Nature Reviews. Drug Discovery·Yu-Hua TsengC Ronald Kahn
Sep 21, 2012·International Journal of Molecular Medicine·Naoko YagishitaToshihiro Nakajima

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