Interruption of the enterohepatic circulation of digitoxin by cholestyramine. II. Effect on metabolic disposition of tritium-labeled digitoxin and cardiac systolic intervals in man

The Journal of Clinical Investigation
J H CaldwellN J Greenberger

Abstract

Previous studies of digitalis glycoside metabolism and excretion have indicated that these compounds undergo a significant enterohepatic cycle in some species. It has been suggested that the existence of such a cycle in man contributes to the prolonged action of certain cardiac glycosides. Previous studies have demonstrated that cholestyramine binds digitoxin and digoxin in vitro and accelerates the metabolic disposition of digitoxin in rats and guinea pigs, presumably by interrupting the enterohepatic circulation. In order to assess the role of the enterohepatic circulation in the metabolism of digitalis glycosides in humans, maintenance doses of cholestyramine were administered to 7 of 15 normal human subjects beginning 8 hr after digitalization with 1.2 mg of digitoxin-(3)H. All subjects had frequent measurements of serum radioactivity, left ventricular ejection time (LVET), and electromechanical systole (QS(2)), the latter recorded as the interval from onset of Q wave to first major component of second heart sound. Measurement of the LVET and QS(2) intervals affords a sensitive index of the cardiac response to digitalis. In addition, chloroform extraction of serum was performed to separate unchanged digitoxin and active met...Continue Reading

References

May 1, 1970·The American Journal of the Medical Sciences·T W Smith, E Haber
Jun 1, 1968·The American Journal of the Medical Sciences·J E Doherty
Jan 1, 1970·The American Journal of the Medical Sciences·A M Weissler, C D Schoenfeld
Apr 1, 1970·Annals of Internal Medicine·R W JelliffeJ G Wagner

Citations

Feb 1, 1975·Journal of Clinical Pharmacology·D E Hutcheon
Jan 1, 1990·Journal of Clinical Pharmacology·S C ForlandR E Cutler
May 23, 2001·Archives of Biochemistry and Biophysics·L LeblancT Borgford
Jan 1, 1983·European Journal of Clinical Pharmacology·J T CallaghanD B Hunninghake
Jan 1, 1982·Pharmacology & Therapeutics·K O Haustein
Sep 3, 1993·Biochimica Et Biophysica Acta·Y M Liou, F Fuchs
Mar 7, 1996·Biochimica Et Biophysica Acta·J M AraminiH J Vogel
May 2, 1996·Biochimica Et Biophysica Acta·T KobayashiJ H Collins
Jul 7, 1973·Lancet·G R Thompson, A M Gotto
Sep 27, 2000·Biochimica Et Biophysica Acta·X ZhaoJ H Collins
May 1, 1985·Journal of the American College of Cardiology·T W Smith
May 1, 1985·Journal of the American College of Cardiology·F I Marcus
Dec 1, 1994·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H H BoersmaA W Konings
Nov 15, 1973·The New England Journal of Medicine·T W Smith, E Haber
Jan 8, 2005·The New England Journal of Medicine·Michael M Ritter
Apr 11, 1975·European Journal of Clinical Investigation·A Sedaghat, E H Ahrens
Jan 1, 1982·Quarterly Reviews on Drug Metabolism and Drug Interactions·B F Johnson, D R Urbach
Jan 1, 1984·Drug Metabolism Reviews·Z H Israili, P G Dayton
Jan 1, 1987·Medical Toxicology·L C Knodel, R L Talbert
Mar 19, 2016·Drug Metabolism Reviews·Mohd Yaseen MalikJawahar Lal
Sep 20, 1973·The American Journal of Cardiology·J F Williams
Oct 1, 1975·Angiology·H R Casdorph
Oct 1, 1985·Journal of Clinical Pharmacology·T W Smith
Aug 1, 1994·Biopharmaceutics & Drug Disposition·M A al-MeshalM W Gouda
Jan 1, 1976·Annals of the New York Academy of Sciences·A Hurwitz, D L Azarnoff
Jul 1, 1987·Diabetes/metabolism Reviews·M F Lopes-Virella, J A Colwell
Aug 12, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·C D Klaassen, Julia Yue Cui
Aug 30, 2001·European Journal of Clinical Investigation·G G BelzU Osowski
Jan 1, 1983·Drug Intelligence & Clinical Pharmacy·A M BaciewiczG L Lipscomb
Oct 1, 1975·CRC Critical Reviews in Toxicology·C D Klaassen

Related Concepts

Carotid Arteries
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