Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice

American Journal of Physiology. Endocrinology and Metabolism
Sébastien M LabbéDenis Richard

Abstract

Brown adipose tissue (BAT) thermogenesis is a key controller of energy metabolism. In response to cold or other adrenergic stimuli, brown adipocytes increase their substrate uptake and oxidative activity while uncoupling ATP synthesis from the mitochondrial respiratory chain activity. Brown adipocytes are found in classic depots such as in the interscapular BAT (iBAT). They can also develop in white adipose tissue (WAT), such as in the inguinal WAT (iWAT), where their presence has been associated with metabolic improvements. We previously reported that the induction of oxidative metabolism in iWAT is low compared with that of iBAT, even after sustained adrenergic stimulation. One explanation to this apparent lack of thermogenic ability of iWAT is the presence of an active iBAT, which may prevent the full activation of iWAT. In this study, we evaluated whether iBAT denervation-induced browning of white fat enhanced the thermogenic activity of iWAT following cold acclimation, under beta-3 adrenergic stimulation (CL 316,243). Following a bilateral denervation of iBAT, we assessed energy balance, evaluated the oxidative activity of iBAT and iWAT using 11C-acetate, and quantified the dynamic glucose uptake of those tissues using 2-d...Continue Reading

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Citations

Jan 29, 2019·Frontiers in Physiology·Bàrbara ReynésAndreu Palou
Dec 18, 2019·Journal of Physiology and Biochemistry·Ismael González-GarcíaCristina Contreras
Nov 7, 2019·International Journal of Molecular Sciences·Joseph FranklOrhan K Öz
Dec 22, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Xiao-Wei JiaYan Gao
Jun 24, 2021·Physiology·Heike MünzbergJi Suk Chang
Sep 21, 2021·American Journal of Physiology. Endocrinology and Metabolism·Érique CastroWilliam T Festuccia

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Methods Mentioned

BETA
ELISA
Assay
PCR
electrophoresis
X-ray

Software Mentioned

Graph Pad Prism

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