Intersection between gonadal function and vascular aging in women

Journal of Applied Physiology
Kerrie L Moreau

Abstract

Vascular aging, characterized by endothelial dysfunction and large elastic arterial stiffening, is a major risk factor for age-associated cardiovascular disease (CVD). Although women have a lower prevalence of CVD until midlife, prevalence rates increase rapidly coincident with the menopausal transition to match those observed in men. The menopausal transition, or perimenopause, is a chaotic period that is associated with increased symptoms (e.g., hot flashes, depressed mood, anxiety, sleep disturbances) and CVD risk factors due to changes in the hormonal environment. Because these quality of life factors and CVD risk factors also change with aging, the arteries of women appear to endure a double insult. Our laboratory has been investigating how changes in gonadal function and hormone levels with the menopause transition impacts the vascular aging process in healthy women. Our work has shown that vascular endothelial function progressively declines, and large elastic arterial stiffness is greater across the stages of the menopausal transition. This acceleration in vascular aging may be due to the loss of vasodilatory, antioxidant, anti-inflammatory, and antiproliferative effects of estradiol on the vascular wall. This minirevie...Continue Reading

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Citations

Jun 8, 2018·Journal of Applied Physiology·Douglas R Seals, Lacy M Alexander
May 12, 2019·The Journal of Physiology·Douglas R SealsKerrie L Moreau
Sep 29, 2020·Current Heart Failure Reports·Andrew OnegliaC Noel Bairey Merz
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Aug 29, 2021·Heart, Lung & Circulation·Ute SeelandUNKNOWN Sex and Gender VascAgeNet Expert Group

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