PMID: 9430769Feb 7, 1998Paper

Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species

Journal of Veterinary Pharmacology and Therapeutics
J E RiviereA L Craigmill

Abstract

The purpose of this study was to apply the method of allometric analysis to a study of the comparative disposition of veterinary drugs using the Food Animal Residue Avoidance Databank (FARAD) as a source of the comparative pharmacokinetic data. An initial filtration of the FARAD data was performed in order to exclude drugs for which no pharmacokinetic data were available, in at least four species the route of administration was other than intravenous, and the matrix was different from blood, plasma or serum. This process restricted the study to a total of 44 candidate drugs. The primary pharmacokinetic parameter selected for study was half-life (t1/2). As this parameter is a composite of clearance (Cl) and volume of distribution (Vd), it was considered to be the most robust for interspecies scaling. Volume of distribution at steady state (Vdss) and clearance showed weak allometric correlations with weight across species. The relationships between body weight and elimination half-life (51/2 beta) were determined for this selected group of drugs by using the empirically determined function Y = a Wb. The function Y represents the parameter of concern (half-life), a is a coefficient typical of every drug (intercept), W is the speci...Continue Reading

Citations

May 8, 2007·European Journal of Drug Metabolism and Pharmacokinetics·Venkata V PavankuamrNuggehally R Srinivas
Aug 14, 2001·Advanced Drug Delivery Reviews·J E Riviere, M G Papich
Aug 14, 2001·Advanced Drug Delivery Reviews·B M MagnussonM S Roberts
Oct 5, 2002·Advanced Drug Delivery Reviews·Robert P Hunter, Ramiro Isaza
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K Baert, P De Backer
May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·E PulidoR Boivin
Jul 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·T Martín-Jiménez, J E Riviere
Jul 10, 2001·Journal of Veterinary Pharmacology and Therapeutics·J M Musser, K L Anderson
Jul 10, 2001·Journal of Veterinary Pharmacology and Therapeutics·G CastellsC Cristòfol
Nov 7, 2001·Journal of Veterinary Pharmacology and Therapeutics·T Martín-Jiménez, J E Riviere
May 31, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M AtefA M Abd El-Aty
Feb 24, 2009·British Poultry Science·M Ismail, Y A El-Kattan
Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·R W SweeneyP C Bardalaye
Dec 1, 1994·Australian Veterinary Journal·T J NichollsR J Wild
Feb 24, 2000·Australian Veterinary Journal·T M Dyke, T Whittem
Jun 8, 2011·Antimicrobial Agents and Chemotherapy·Brioni R MooreKevin T Batty
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Laurent DubéDenis Bugnon
Dec 16, 2005·The AAPS Journal·Renate ReimschuesselClifford Hodsdon
Mar 21, 2003·AAPS PharmSci·Arthur L Craigmill, Kristy A Cortright
Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Robert P Hunter, Ramiro Isaza
Sep 15, 2009·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Elizabeth M BuntingGeorge V Kollias
Jan 25, 2006·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·A Pasamontes, M P Callao
Jul 6, 2014·Expert Opinion on Drug Metabolism & Toxicology·Qingbiao Huang, Jim E Riviere
Sep 5, 2006·Expert Opinion on Drug Delivery·Thomas W LeonardDavid J Brayden
Feb 3, 2015·Journal of Pharmaceutical Sciences·Mengjie LiJim Riviere
Mar 10, 2010·Journal of Pharmaceutical Sciences·Marilyn N MartinezSanja Modric
Feb 9, 2002·Journal of Pharmaceutical Sciences·Tomás Martín-Jiménez, Jim E Riviere
Nov 16, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Butch Kukanich
Nov 7, 2009·Reproductive Toxicology·Kevin T BattyTimothy M E Davis
May 27, 2008·International Journal of Pharmaceutics·Wenli LvJin Li
Jun 16, 2007·Research in Veterinary Science·Byung-Kwon ParkHyo-In Yun
Jun 14, 2005·British Journal of Clinical Pharmacology·Catherijne A J KnibbeMeindert Danhof
Feb 22, 2005·Journal of Veterinary Pharmacology and Therapeutics·M CouletJ Lohuis
Jun 11, 2009·British Journal of Pharmacology·Vijay Sharma, John H McNeill
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·S K CoxJ Bartges
Jan 8, 2008·Journal of Veterinary Pharmacology and Therapeutics·L K Maxwell, E R Jacobson
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·R GehringJ E Riviere
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·M MartinezR P Hunter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Journal of Veterinary Pharmacology and Therapeutics
T Martin-Jimenez, J E Riviere
Journal of Veterinary Pharmacology and Therapeutics
Iftekhar MahmoodRobert P Hunter
Regulatory Toxicology and Pharmacology : RTP
R E BaynesJ E Riviere
Journal of Veterinary Pharmacology and Therapeutics
L Lashev, R Mihailov
© 2021 Meta ULC. All rights reserved