PMID: 8981101Dec 1, 1996Paper

Interspecies differences in enzymes reacting with organophosphates and their inhibition by paraoxon in vitro

Human & Experimental Toxicology
E Kaliste-KorhonenO Hänninen

Abstract

1 Inhibition of cholinesterases (ChE) and carboxylesterases (CaE) by paraoxon (Px) was studied in vitro in the serum, liver, lung and muscle of mouse, guinea pig, rabbit and man (serum only). Moreover, the role of Px hydrolyzing enzyme (Pxase) in the detoxification of Px was studied by inhibiting its activity with EDTA. 2 The ChE and CaE activities as well as their sensitivity to Px varied in different tissues and species. The ChEs were more sensitive than CaEs to Px except in the liver. The CaE activity in human and rabbit sera was low and resistant to Px, indicating that it may have a minor importance for the binding of Px. 3 The Px-inhibited ChEs were spontaneously reactivated in the mouse and rabbit sera during 24 h. In mouse, also the CaE activity was recovered. The presence of EDTA in the incubation medium prevented this reactivation indicating that Pxase takes part in the reactivation process. 4 In rabbit, the serum Pxase activity was very high suggesting a good Px detoxifying capacity of the rabbit serum. 5 The results show that amounts and sensitivities of esterases to OPs in rodents may markedly differ from that in man. Possible species-related differences in the affinity of ChEs and CaEs for OPs and the OP hydrolyzin...Continue Reading

References

Aug 1, 1975·CRC Critical Reviews in Toxicology·W Junge, K Krisch
Feb 15, 1989·Biochemical Pharmacology·R TraversoM Lotti
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·R T Evans
Feb 1, 1987·Annals of Emergency Medicine·J Tafuri, J Roberts
Mar 30, 1987·Toxicology and Applied Pharmacology·D M MaxwellH L Froehlich
Mar 1, 1982·Journal of Pharmacobio-dynamics·T Matsubara, I Horikoshi
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J E Chambers, R L Carr
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K TuovinenO Hänninen
Jan 1, 1996·Archives of Toxicology·M JokanovićM Maksimović
Jun 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K TuovinenO Hänninen
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·A PlonowskiG Halmos
Sep 17, 2004·Journal of Toxicology and Environmental Health. Part a·S PadillaV C Moser
Apr 20, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Annetta WatsonVeronique Hauschild
Dec 30, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Lucie BartosovaJiri Bajgar
May 1, 2001·Journal of Toxicology. Clinical Toxicology·G PetroianuR Rüfer
Sep 6, 2001·Journal of Pharmaceutical Sciences·I K ReddyN S Bodor
Dec 8, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T WilleF Worek
Sep 16, 2003·Biopharmaceutics & Drug Disposition·D WerdenbergP Langguth
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Anton StangelbergerRobert Vessella
Apr 25, 2015·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ildikó SzabóGábor Mező
Feb 16, 2002·Regulatory Toxicology and Pharmacology : RTP·R C Cochran
Mar 3, 2004·Human & Experimental Toxicology·Chaitali Sinha, Girja S Shukla

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