PMID: 6169638Jan 1, 1981Paper

Interspecies exchange of beta 2-microglobulin and associated MHC and differentiation antigens

Immunogenetics
W SchmidtA R Sanderson

Abstract

Radiolabeled human beta 2-microglobulin (beta 2m) can bind to mouse histocompatibility (H-2) antigens on the cell surface or to partially purified H-2 antigens in solution. The complexes containing human beta 2m and H-2 antigens from C3H (H-2k) mice could be immunoprecipitated specifically with alloantisera, rabbit anti-H-2 xenoantisera, and with monoclonal H-2-specific antibodies. Specific association with H-2 antigens was also observed with other haplotypes. The only exception was B10.D2 (H-2d) from which complexes containing human beta 2m could only be precipitated with anti-H-2-xenosera. Thus radiolabeled human beta 2m can be used as a specific label for mouse H-2 antigens in precipitation and radioimmunoassays. The application of this finding extends to major histocompatibility complex antigens of other species, and to differentiation antigens with primary association with beta 2m.

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Citations

Jan 1, 1992·Archives of Virology·M N WykesG R Shellam
Jan 1, 1982·Journal of Immunological Methods·W R ChurchR A Reisfeld
Jan 1, 1994·Molecular Aspects of Medicine·A MorrisS Young
Jul 1, 1982·Molecular Immunology·L GrafP J Robinson
Aug 1, 1983·Molecular Immunology·L Lögdberg, L Björck
Aug 1, 1995·Immunology and Cell Biology·P PriceJ McCluskey
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W Becker, G N Reeke
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y BushkinR Schwab
Apr 16, 2009·The Journal of Biological Chemistry·Kathleen CorcoranLonnie Lybarger
Jan 1, 1991·Tissue Antigens·F Calabi, A Bradbury
Apr 1, 1990·European Journal of Immunology·A C GilletF A Lemonnier
Jul 16, 2005·Expert Opinion on Biological Therapy·Steve Pascolo
Jan 23, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sigal FishmanF Susan Wong
Oct 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A RoccaM Pla
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dikla BerkoGideon Gross
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alon MargalitGideon Gross

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