PMID: 2501680Jul 1, 1989Paper

Interspecies homology of cytochrome P-450: toxicological significance of cytochrome P-450 cross-reactive with anti-rat P-448-H antibodies in liver microsomes from dogs, monkeys and humans

Mutation Research
K OhtaT Kamataki

Abstract

The mutagenic activation of various promutagens by liver microsomes from dogs, monkeys and humans was investigated. Dog liver microsomes efficiently catalyzed the mutagenic activation of Trp-P-2 and Glu-P-1 followed by IQ and AAF. Monkey liver microsomes were most active in the activation of IQ followed by Glu-P-1, AAF and Trp-P-2. Although there were remarkable individual differences, human liver microsomes were found to be most active in the mutagenic activation of IQ followed by Trp-P-2, Glu-P-1 and AAF. Antibodies against rat P-448-H inhibited the mutagenic activation of Glu-P-1, Trp-P-2 and IQ in rat and dog liver microsomes, and Glu-P-1 and Trp-P-2 in monkey liver microsomes. The activation of Glu-P-1 and IQ in human liver microsomes was also strongly inhibited by anti-P-448-H antibodies. The amounts of cytochrome P-450 cross-reactive with anti-P-448-H antibodies in human liver microsomes highly correlated with the capacity to activate Glu-P-1, Trp-P-2 and IQ but not AAF.

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S T OkinoR H Tukey
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D T MolowaP S Guzelian

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Citations

Jul 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A BeamandB G Lake
Jan 1, 1994·Drug Metabolism Reviews·M Kitada, T Kamataki
Apr 1, 1991·Japanese Journal of Cancer Research : Gann·M KitadaT Kamataki
Nov 26, 2002·Hematology·David G MaloneyJudith A Shizuru
Dec 1, 1994·The Journal of Applied Bacteriology·A M Warhurst, C A Fewson
Jan 22, 1998·Archives of Biochemistry and Biophysics·T MoriT Kamataki

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