Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

PMID: 7120049Apr 1, 1982Paper

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

Journal of Pharmacokinetics and Biopharmaceutics

H Boxenbaum

Abstract

No abstract listed.

References

Scaling of renal functions in mammals

Sep 1, 1975·Comparative Biochemistry and Physiology. A, Comparative Physiology·N A Edwards

Evolution of human longevity: a critical overview

Feb 1, 1979·Mechanisms of Ageing and Development·R G Cutler

A time to die

Jan 1, 1975·Life Sciences·W D Denckla

Commentary: a physiological approach to hepatic drug clearance.

Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand

Metabolic turnover rate: a physiological meaning of the metabolic rate per unit body weight

Sep 1, 1975·Journal of Theoretical Biology·M Kleiber

Allometry and size in ontogeny and phylogeny

Nov 1, 1966·Biological Reviews of the Cambridge Philosophical Society·S J Gould

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin

Apr 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·H Boxenbaum

Scaling of physiological processes in homeothermic animals

Jan 1, 1981·Annual Review of Physiology·W A Calder

The evolution of human longevity

Aug 1, 1980·Medical Hypotheses·S Seely

Imperfection: biochemical phobias and metabolic ambivalence

Jan 1, 1959·Perspectives in Biology and Medicine·D L DRABKIN

Life span of red blood cell

Jul 1, 1959·Physiological Reviews·N I BERLINS M WEISSMAN

Studies of I-131-albumin catabolism and distribution in normal young male adults

Jun 1, 1962·The Journal of Clinical Investigation·W L BEEKENR S STEMLER

THE ANALYSIS OF BIOLOGICAL SIMILARITY

Jan 1, 1963·Advances in Biological and Medical Physics·W R STAHL

RELATIONSHIP OF LIVER COMPOSITION TO INTENSITY OF PROTEIN METABOLISM IN DIFFERENT MAMMALS

Aug 8, 1964·Nature·H N MUNRO, E D DOWNIE

PHYSIOLOGICAL TIME

Dec 18, 1931·Science·A Carrel

Quantitative Relations in the Physiological Constitutions of Mammals

Jun 10, 1949·Science·E F Adolph

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

Abstract

References

Scaling of renal functions in mammals

Evolution of human longevity: a critical overview

A time to die

Commentary: a physiological approach to hepatic drug clearance.

Metabolic turnover rate: a physiological meaning of the metabolic rate per unit body weight

Allometry and size in ontogeny and phylogeny

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin

Scaling of physiological processes in homeothermic animals

The evolution of human longevity

Imperfection: biochemical phobias and metabolic ambivalence

Life span of red blood cell

Studies of I-131-albumin catabolism and distribution in normal young male adults

THE ANALYSIS OF BIOLOGICAL SIMILARITY

RELATIONSHIP OF LIVER COMPOSITION TO INTENSITY OF PROTEIN METABOLISM IN DIFFERENT MAMMALS

PHYSIOLOGICAL TIME

Quantitative Relations in the Physiological Constitutions of Mammals

Citations

Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse

Prediction of ACNU plasma concentration-time profiles in humans by animal scale-up

The use of toxicokinetics for the safety assessment of drugs acting in the brain

Equation chapter 1 section 1A new method for predicting human hepatic clearance from in vitro experimental data using molecular descriptors

Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species

Pharmacokinetics of oxamniquine in rabbit and rat

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

Application of allometry principles for the prediction of human pharmacokinetic parameters for irbesartan, a AT1 receptor antagonist, from animal data.

Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator

Use of bile correction factors for allometric prediction of human pharmacokinetic parameters of torcetrapib, a facile cholesteryl ester transfer protein inhibitor.

Prediction of drug clearance in humans from laboratory animals based on body surface area

Metabotropic glutamate receptor modulation, translational methods, and biomarkers: relationships with anxiety.

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys

Interspecies pharmacokinetics of xymedon

Allometric scaling of pegylated liposomal anticancer drugs.

Applications of minimal physiologically-based pharmacokinetic models

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

Prediction of human bioavailability from human oral administration data and animal pharmacokinetic data without data from intravenous administration of drugs in humans.

Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.

Approaches for predicting human pharmacokinetics using interspecies pharmacokinetic scaling

Intravenous prediction of human pharmacokinetic parameters for ketorolac, a non-steroidal anti-inflammatory agent, using allometry approach

Inter-species extrapolation of pharmacokinetic data of three prostacyclin-mimetics

Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary

Use of quantitative modelling in methylene chloride risk assessment

Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamics

The allometric approach for interspecies scaling of pharmacokinetic parameters

Integrated pharmacokinetic-pharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody

Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin

An allometric model for predicting blood ethanol elimination in mammals

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

Veterinary drug delivery: potential for skin penetration enhancement

Comparative efficacies of levofloxacin and ciprofloxacin against Streptococcus pneumoniae in a mouse model of experimental septicaemia

Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor

Prediction of pharmacokinetic properties using experimental approaches during early drug discovery

Allometric analysis of thiamphenicol disposition among seven mammalian species

Scaling for size: some implications for paediatric anaesthesia dosing

Allometric analysis of doxycycline pharmacokinetic parameters

The allometric approach for interspecies scaling of pharmacokinetics and toxicity of anti-cancer drugs

Compared plasma and brain pharmacokinetics of clomipramine and its metabolite demethylclomipramine in two strains of mice (NMRI and CD1)

Tissue dosimetry for reactive metabolites

Proposals for improving risk assessment in reproductive toxicology

Extrapolation from animals to man. The integration of pharmacokinetics and pharmacodynamics

Strategies in selecting an agent for clinical trials

Pharmacokinetics of 2',3'-dideoxycytidine in rats: application to interspecies scale-up

Interspecies differences and scaling for the pharmacokinetics of xanthine derivatives

Comparative pharmacokinetics and interspecies scaling of amphotericin B in several mammalian species

Interspecies scaling: predicting volumes, mean residence time and elimination half-life. Some suggestions

Forecasting cephalosporin and monobactam antibiotic half-lives in humans from data collected in laboratory animals.

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