PMID: 8587044Nov 1, 1995Paper

Interspecies scaling of interferon disposition and comparison of allometric scaling with concentration-time transformations

Journal of Pharmaceutical Sciences
T LaveR C Chou

Abstract

Interspecies scaling is used to extrapolate pharmacokinetic parameters from animals to humans, through the application of physiologically based models, by empirical allometric procedures, or using concentration-time transformations. The aim of this study was to compare the accuracies of the last two methods for predicting the pharmacokinetic parameters and concentration-time curves in humans. In the first part of this study, interspecies scaling techniques were applied to a hypothetical drug (extracellular distribution and elimination through glomerular filtration), to examine the influence of various laboratory animals (mouse, rat, cynomolgus monkey and dog) on the parameters predicted for man. The same techniques were also applied to interferon-alpha A, using the literature data for various animal species. The kinetic parameters predicted in man were then compared to the values published for man. Our theoretical example showed that, for allometric scaling, each species has a very different influence on the prediction in human. With the approach using concentration-time transformations, however, each animal species potentially makes a similar contribution to the prediction for man. Based on the pharmacokinetic data published f...Continue Reading

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Citations

Jan 26, 2002·European Journal of Drug Metabolism and Pharmacokinetics·X D Liu, J Chen
Sep 29, 2001·Advanced Drug Delivery Reviews·B AgoramM B Bolger
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Makrem Ben ReguigaRobert Farinotti
May 4, 2010·Biopharmaceutics & Drug Disposition·Weirong Wang, Thomayant Prueksaritanont
May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·K SchneiderM Hassauer
Jul 7, 1998·Toxicology and Applied Pharmacology·M Bazin-RedureauJ M Scherrmann
Mar 12, 2015·Toxicology and Applied Pharmacology·Séverine H ColletVéronique Gayrard
Sep 7, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yeamin HuhMeihau Rose Feng
Nov 26, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shinji YamazakiTatiana Koudriakova
Jun 20, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sukyung Woo, William J Jusko
Jul 20, 2007·The Journal of Pharmacy and Pharmacology·Urban Fagerholm
May 28, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn

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