PMID: 6107379Apr 1, 1980Paper

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin

Journal of Pharmacokinetics and Biopharmaceutics
H Boxenbaum

Abstract

The literature was reviewed to obtain data from 11 mammalian species on liver weight, hepatic blood flow, and antipyrine intrinsic clearance. It was demonstrated that liver weight and hepatic blood flow in all species could be readily related to body weight by a simple equation. Additionally, hepatic blood flow in all species was directly proportional to liver weight. With the exception of man, antipyrine intrinsic clearance was also directly proportional to liver weight. Man's intrinsic clearance was approximately one-seventh of that which would be predicted from other species. Data on benzodiazepines and phenytoin showed a similar pattern.

References

Feb 1, 1976·Journal of Pharmacokinetics and Biopharmaceutics·S A KaplanS Cotler
Oct 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·I BekerskyS A Kaplan
Jan 1, 1976·Perspectives in Biology and Medicine·R H Wickramasinghe, C A Villee
Jun 1, 1975·Clinical Pharmacology and Therapeutics·T F BlaschkeM Rowland
Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Jan 1, 1973·The Journal of Pharmacy and Pharmacology·J D Baty, D A Evans
Jan 1, 1973·Journal of Pharmaceutical Sciences·G Levy, J J Ashley
Feb 1, 1973·Journal of Pharmaceutical Sciences·Y SaitoT Suzuki
Nov 1, 1973·Journal of Pharmaceutical Sciences·M A SchwartzA S Leon
Dec 1, 1973·Comparative and General Pharmacology·J D Baggot, L E Davis
Apr 1, 1974·Journal of Pharmaceutical Sciences·S A KaplanR E Weinfeld
May 1, 1972·Biochemical Pharmacology·D W ShoemanB M Boulos
Aug 1, 1971·Journal of Pharmaceutical Sciences·K B BischoffJ A Longstreth
Nov 1, 1970·Journal of Pharmaceutical Sciences·S A KaplanR E Weinfeld
Jan 1, 1971·Chemical & Pharmaceutical Bulletin·H YoshimuraH Tsukamoto
Aug 1, 1968·Biochemical Pharmacology·H YoshimuraH Tsukamoto
Apr 1, 1969·The Annals of Thoracic Surgery·W A CookB G Bass

❮ Previous
Next ❯

Citations

Mar 20, 1998·Journal of Clinical Pharmacology·S M TroyS T Chiang
Jan 1, 1987·Archives of Toxicology·J G FilserN Fedtke
Jan 1, 1993·Journal of Neural Transmission. General Section·S O OgrenM Widman
Jan 1, 1990·Archives of Toxicology·A J StreeterD L Logsdon
Jan 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·Y TanakaS Ninomiya
Apr 1, 1984·European Journal of Drug Metabolism and Pharmacokinetics·H Boxenbaum, J B Fertig
Sep 14, 2001·European Journal of Drug Metabolism and Pharmacokinetics·A M MazaJ L Pedraz
Apr 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·F P Abramson
Jan 1, 1995·European Journal of Drug Metabolism and Pharmacokinetics·B VallèsP Coassolo
Dec 6, 2011·Archives of Pharmacal Research·Hee Eun Kang, Myung Gull Lee
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·J W Prothero
Jul 1, 1990·Domestic Animal Endocrinology·X BerthelotP L Toutain
Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·W A RitschelA S Hussain
Jan 1, 1997·Pharmacology & Therapeutics·T IwatsuboY Sugiyama
Sep 9, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·K OgawaraT Kimura
Jun 9, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonA G Renwick
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K BeaumontJ Bennett
May 12, 2001·Journal of Veterinary Pharmacology and Therapeutics·P L ToutainS Metge
Dec 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·S A Brown, S D Forrester
Dec 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·S A BrownS M Hartsfield
Apr 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·Z Ben-ZviR Yagil
Nov 1, 1995·Clinical and Experimental Pharmacology & Physiology·J W Paxton
Mar 1, 1992·Risk Analysis : an Official Publication of the Society for Risk Analysis·P J Robinson
Sep 1, 1990·Pharmacology & Toxicology·R D MoshaP Nielsen
Oct 1, 1993·Journal of Pineal Research·X BerthelotP L Toutain
Jul 1, 1992·The Journal of Pharmacy and Pharmacology·Y TsunekawaT Nabeshima
Mar 19, 2009·The Journal of Pharmacology and Experimental Therapeutics·Huixia ZhangJashvant D Unadkat
May 30, 2009·The Journal of Pharmacology and Experimental Therapeutics·Huixia ZhangJashvant D Unadkat
Jun 4, 1999·Journal of Clinical Pharmacology·L IavaroneG C Preston
Apr 1, 1988·Environmental Health Perspectives·F G Standaert
Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Robert P Hunter, Ramiro Isaza
Aug 3, 2013·Biomechanics and Modeling in Mechanobiology·Jennifer H SiggersRodolfo Repetto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.