Interspecies Variation of Outer Retina and Choriocapillaris Imaged With Optical Coherence Tomography

Investigative Ophthalmology & Visual Science
Petr SoukupSimon Pot

Abstract

The purpose of this study is to assess with spectral-domain optical coherence tomography (OCT) the interspecies variation of outer retinal morphology and identification of choriocapillaris in four research animal species. Spectralis HRA+OCT images acquired from locations dorsal, central, and ventral to the optic disc in healthy, anesthetized animals were evaluated by two independent readers. First, the number of OCT B-scans on which a choriocapillaris layer could clearly be identified was determined and quantified, and B-scans were correlated with histology. Second, B-scans demonstrating the highest number of discernable individual outer retinal bands (ORBs) were defined as ideal presentation and quantified. Interrater agreement was evaluated. Five-hundred seventy-four B-scans from 96 subjects were evaluated. The choriocapillaris layer was identified in 100.0% of minipig, 70.8% of rabbit, 75.4% of pigmented rat, 77.7% of albino rat, 56.5% of pigmented mouse, and 50.8% of albino mouse OCT scans. The percentage of ideal ORB presentation in B-scans was 11.7% in minipigs, 73.8% in rabbits, and 80.0%, 91.0%, 28.5%, and 62.5% in pigmented rats and mice and albino rats and mice, respectively. The interrater evaluation for both attribu...Continue Reading

References

Nov 15, 1979·The Journal of Comparative Neurology·L D Carter-Dawson, M M LaVail
Mar 22, 1974·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M L Beauchemin
Sep 12, 1971·Documenta Ophthalmologica. Advances in Ophthalmology·A Hughes
May 1, 1995·Ophthalmology·M R HeeJ G Fujimoto
Aug 12, 1994·Brain Research. Developmental Brain Research·A SzélT van Veen
Jun 9, 2001·Veterinary Ophthalmology·M.J. ChandlerE.O. MacKay
Jun 22, 2002·Experimental Eye Research·Anita Hendrickson, David Hicks
Mar 27, 2003·Investigative Ophthalmology & Visual Science·Martin GloesmannWolfgang Drexler
Jan 24, 2004·Veterinary Ophthalmology·F J OllivierA M Komáromy
Apr 23, 2005·The Journal of Comparative Neurology·Mónica GarcáElena Vecino
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Vivek J SrinivasanJames G Fujimoto
Aug 19, 2008·Investigative Ophthalmology & Visual Science·Carla J AbbottMichael J Pianta
Dec 17, 2008·Investigative Ophthalmology & Visual Science·Mineo KondoHiroko Terasaki
Aug 8, 2009·Investigative Ophthalmology & Visual Science·Gesine HuberM Dominik Fischer
Dec 17, 2009·Investigative Ophthalmology & Visual Science·Sandeep GroverKakarla V Chalam
Jan 28, 2010·American Journal of Ophthalmology·Daniel F KiernanSeenu M Hariprasad
Oct 27, 2010·PloS One·Gesine HuberSusanne C Beck
Apr 16, 2011·Investigative Ophthalmology & Visual Science·Michelle L GabrieleJoel S Schuman
May 7, 2011·Analytical and Bioanalytical Chemistry·Sebastian MarschallPeter E Andersen
Nov 5, 2011·Veterinary Ophthalmology·Elena Hernandez-MerinoSinisa D Grozdanic
Dec 2, 2011·Investigative Ophthalmology & Visual Science·Katharina HeinMathias Bähr
Mar 8, 2012·Investigative Ophthalmology & Visual Science·Jesse B SchallekDaniel Y Ts'o
Mar 20, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Luís A AranaMark S Humayun
Apr 14, 2012·Investigative Ophthalmology & Visual Science·Travis J BaileyDavid R Hyde
May 12, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Akio OishiYasuo Kurimoto
Nov 6, 2012·Ophthalmology·Richard F Spaide
Nov 22, 2012·Investigative Ophthalmology & Visual Science·Diana C Lozano, Michael D Twa
May 31, 2013·Acta Ophthalmologica·Stefan KoinzerJohann Roider

❮ Previous
Next ❯

Citations

Jul 11, 2020·Investigative Ophthalmology & Visual Science·Andreas PollreiszChristine A Curcio
Feb 24, 2021·Investigative Ophthalmology & Visual Science·S P B Sardar PashaTimothy W Corson
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.