Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa

The ISME Journal
Freya HarrisonAngus Buckling

Abstract

Both intra- and interspecific interactions between microbes are likely to play an important role in determining the severity of microbial infections. Here, we study the impact of interactions between coinfecting opportunistic pathogens Staphylococcus aureus and Pseudomonas aeruginosa on both phenotypic and genetic changes in a P. aeruginosa social trait, the production of iron-scavenging siderophores. Siderophores are facultatively upregulated in response to iron limitation and play a key role in determining the virulence of microbial infections. Siderophore production is metabolically expensive to individual producers but benefits the group as a whole because siderophores can be used by all cells in the vicinity with siderophore receptors. Hence, populations of siderophore producers can be invaded by nonproducing cheats. Previous work has shown that P. aeruginosa can lyse S. aureus, supplying a source of free iron. We therefore hypothesized that the presence of S. aureus might result in facultative downregulation of siderophore production, and in turn, reduced selection for siderophore cheats. We tested this hypothesis by evolving P. aeruginosa in the presence and absence of free iron and S. aureus, in a fully factorial design...Continue Reading

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