Interspecific hybridization between an anural and urodele ascidian: differential expression of urodele features suggests multiple mechanisms control anural development

Developmental Biology
B J Swalla, W R Jeffery

Abstract

Anural development in the ascidian Molgula occulta was examined using tissue-specific markers and interspecific hybridization. Unlike most ascidians, which develop into a swimming tadpole larva (urodele development), M. occulta eggs develop into a tailless slug-like larva (anural development) which metamorphoses into an adult. M. occulta embryos show conventional early cleavage patterns, gastrulation, and neurulation, but then diverge from the urodele developmental mode during larval morphogenesis. M. occulta larvae do not contain a pigmented sensory cell in their brain or form a tail with differentiated notochord and muscle cells. As shown by in situ hybridization with cloned probes and analysis of in vitro translation products, M. occulta embryos do not accumulate high levels of alpha actin or myosin heavy chain mRNA. In contrast, acetylcholinesterase is expressed in muscle lineage cells, indicating that various muscle cell features are differentially suppressed. M. occulta embryos also lack tyrosinase activity, suggesting that suppression of brain pigment cell differentiation occurs at an early step in development. M. occulta eggs fertilized with sperm from Molgula oculata (a closely related urodele species) develop into hyb...Continue Reading

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Citations

Apr 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·W R Jeffery, B J Swalla
Apr 1, 1995·Journal of Molecular Evolution·K A HadfieldW R Jeffery
Oct 1, 1992·Developmental Biology·W R Jeffery, B J Swalla
Aug 1, 1997·Development, Growth & Differentiation·A CaraccioloA Palumbo
Mar 2, 2005·Zoological Science·Takehiro Kusakabe
Feb 9, 2005·Evolution; International Journal of Organic Evolution·Glenys D Gibson, A Jamie F Gibson
Apr 22, 2004·Evolution & Development·William R Jeffery
May 2, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shungo Kano
Nov 11, 2014·Genesis : the Journal of Genetics and Development·R EspositoA Spagnuolo
Mar 15, 2000·Developmental Biology·K J PetersonE H Davidson
Aug 1, 1993·Zygote : the Biology of Gametes and Early Embryos·W R Jeffery, B J Swalla
Jun 11, 2002·Evolution & Development·Norio TakadaBillie J Swalla
Mar 29, 2002·Journal of Morphology·Kathleen K Smith
Mar 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L MaW R Jeffery
Sep 1, 1991·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·William R Bates, Joan E Mallett
Mar 1, 1993·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·William R Jeffery
Nov 1, 1993·Microscopy Research and Technique·B J Swalla
Jul 22, 2017·EvoDevo·Claudia RacioppiFilomena Ristoratore
Jun 30, 2019·EvoDevo·Florian Razy-Krajka, Alberto Stolfi
May 12, 2011·Development·Patrick Lemaire
Apr 22, 2021·Integrative and Comparative Biology·Alexander C A FodorBillie J Swalla

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