PMID: 9528916Apr 7, 1998Paper

Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat

Journal of Neurotrauma
M J BellE K Jackson

Abstract

Adenosine is a putative neuroprotectant in ischemia, but its role after traumatic brain injury (TBI) is not clear. Metabolites of adenosine, particularly inosine and hypoxanthine, are markers of ischemia and energy failure. Adenosine triphosphate (ATP) breakdown early after injury and metabolism of cyclic adenosine monophosphate (cAMP) are potential sources of adenosine. Further delineation of the magnitude, location, time course, and source of production of adenosine after TBI is needed. We measured adenosine, inosine, and hypoxanthine in brain interstitial fluid after controlled cortical impact (CCI) in the rat. Rats (n = 15) were prepared for TBI induced by CCI. A microdialysis probe was placed in the cortex, and samples were collected every 10 min. After 3 h of equilibration, the catheter was removed, CCI was performed (4 m/sec, depth 2.5 mm), and the catheter was replaced. In the shams, the catheter was removed and replaced without CCI. The injury group included rats (n = 10) subjected to CCI. Within the injury group, the microdialysis probe was placed in the center of the eventual contusion (center, n = 5) or in the penumbral region (penumbra, n = 5). Purine metabolites were measured using ultraviolet-based high-pressure ...Continue Reading

References

Jan 1, 1975·European Journal of Pharmacology·J W PhillisJ J Limacher
Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R MenoH R Winn
Apr 1, 1990·Journal of Applied Physiology·N LaudignonJ V Aranda
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonU Ungerstedt
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L HilleredU Ungerstedt
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S MoriiH R Winn
Apr 1, 1988·British Journal of Pharmacology·N G BoweryA L Hudson
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D G Van WylenR M Berne
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A RudolphiH J Hinze
Dec 1, 1994·Journal of Neurotrauma·J T PovlishockT K McIntosh
Sep 22, 1994·European Journal of Pharmacology·D K Von LubitzK A Jacobson
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P HeadrickR Vink
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J G ZhouH R Winn
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R MenoH R Winn

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Citations

Feb 13, 1999·European Journal of Pharmacology·D K Von Lubitz
Jun 4, 1999·European Journal of Pharmacology·D K von Lubitz
Sep 19, 2009·Cell Death and Differentiation·D BoisonB B Fredholm
Oct 3, 2012·Journal of Neurotrauma·Mayumi L PrinsDavid A Hovda
May 25, 2001·Critical Care Medicine·F Garcia SorianoC Szabó
Feb 8, 2014·Brain Research·Shlomit DachirEsther Shohami
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L I BenowitzN Irwin
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peng ChenLarry I Benowitz
Apr 3, 2001·Expert Opinion on Investigational Drugs·D K von Lubitz
Jun 16, 1999·Clinical and Experimental Hypertension : CHE·E M GoldingR M Bryan
Feb 11, 2000·Annals of the New York Academy of Sciences·D K von LubitzR C Lin
Mar 27, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Amy K Wagner, Kevin T Zitelli
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekChien Ho
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekEdwin K Jackson
Oct 6, 2007·Experimental Neurology·Coleen M AtkinsW Dalton Dietrich
Sep 12, 2015·Journal of Pharmaceutical and Biomedical Analysis·Pei LiLing-Yi Kong
Mar 1, 2012·Journal of Neurochemistry·Jonathan D VerrierEdwin K Jackson
Apr 26, 2001·Neurological Research·Y XiongC P Lee
Jan 10, 2012·Experimental Neurology·Theresa A LusardiDetlev Boison
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick M. KochanekLarry W. Jenkins
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L Virág, C Szabó
Mar 16, 2017·Journal of Neurochemistry·Edwin K JacksonPatrick M Kochanek

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