Interstitial alterations in renal cortex in acute tubular necrosis (ATN) post-renal transplantation and in patients with ATN not related to renal transplant

Clinical Transplantation
Miguel Moyses NetoTerezila M Coimbra

Abstract

Abnormalities of renal function with long-term implications can persist after acute tubular necrosis (ATN), probably because of permanent loss of nephrons. Residual areas of fibrosis are also observed in the renal cortex post-ATN. In this study, we investigate the interstitial alterations post-ATN using histological and immunohistochemical methods. We studied 11 patients with ATN of different etiologies and 19 patients with ATN post-renal transplantation. Eleven patients with ATN post-renal transplantation and one with ATN not related to renal transplantation were submitted to more than one biopsy because of delayed renal function recovery. The immunohistochemical studies were performed using alpha-smooth muscle-actin (alpha-SM-actin), endothelin, nuclear factor-kappaB (NF-kappaB), Jun-N-terminal kinase (p-JNK) and fibronectin antibodies. We also analyzed the urinary content of transforming growth factor-beta (TGF-beta) during the acute phase of ATN. The immunohistochemical studies showed increased alpha-SM-actin, fibronectin, endothelin, p-JNK and NF-kappaB staining in the tubulointerstitium area from the renal cortex of all patients when compared with controls (p < 0.001), and these increase persisted in the patients submitte...Continue Reading

References

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Citations

Apr 7, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John KanellisDavid J Nikolic-Paterson
Jul 21, 2007·Kidney & Blood Pressure Research·Andréa G C FlávioTerezila M Coimbra
Aug 16, 2008·Renal Failure·Regina C R M AbdulkaderDenise M A C Malheiros
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W GwinnerM Mengel
Dec 14, 2018·Journal of the American Society of Nephrology : JASN·Atsuko Y HigashiGregory R Dressler
Jun 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yinyin YeJunwei Yang

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