Interstitial cells of Cajal are decreased in patients with gastroschisis associated intestinal dysmotility

Journal of Pediatric Surgery
Elke Zani-RuttenstockNiyi Ade-Ajayi

Abstract

Gastroschisis associated intestinal dysmotility (GAID) is poorly understood. Animal experiments suggest that interstitial cells of Cajal (ICC), play an important role. Infants with gastroschisis (GS) and GAID (time to full feed >42days) were selected. Age matched GS and control (NEC, ileal atresia, malrotation, and volvulus) samples from primary (T1) and secondary (T2) time points underwent standard histopathology and immunohistochemistry for identification of ICC, followed by evaluation of ICC numbers, distribution, morphology, relation to ganglion cells, and myenteric plexus architecture. Groups were compared using parametric and nonparametric tests. Twelve patients had samples available for histopathological evaluation. GAID patients had a significantly lower total number of ICCs than controls (3 vs. 8, P<0.0029). ICC number at T1 was 2.5 vs. 6 (P=0.0629) and significantly lower at T2. (3.5 vs. 11, P=0.0124). GAID patients did not show a significant increase of ICC from T1 to T2. Controls showed a significant increase of ICC over time (6 vs. 11, P=0.0408). Intestinal samples from infants with GAID who underwent stoma formation demonstrated fewer ICC than controls. There was no improvement or cell recovery during the study pe...Continue Reading

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Citations

Jan 19, 2019·Clinical and Translational Science·Valentina ShakhnovichSusan M Abdel-Rahman
May 23, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Allison J WuKara L Calkins
May 29, 2021·World Journal of Clinical Cases·Bei-Bei FuYing Fan

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