Interstitial cells of Cajal in the deep muscular plexus mediate enteric motor neurotransmission in the mouse small intestine

The Journal of Physiology
Sean M WardKenton M Sanders

Abstract

Interstitial cells of Cajal (ICC) provide important regulatory functions in the motor activity of the gastrointestinal tract. In the small intestine, ICC in the myenteric region (ICC-MY), between the circular and longitudinal muscle layers, generate and propagate electrical slow waves. Another population of ICC lies in the plane of the deep muscular plexus (ICC-DMP), and these cells are closely associated with varicose nerve terminals of enteric motor neurons. Here we tested the hypothesis that ICC-DMP mediate excitatory and inhibitory neural inputs in the small bowel. ICC-DMP develop largely after birth. ICC-DMP, with receptor tyrosine kinase Kit-like immunoreactivity, appear first in the jejunum and then in the ileum. We performed electrophysiological experiments on mice immediately after birth (P0) or at 10 days post partum (P10) to determine whether neural responses follow development of ICC-DMP. At P0, slow-wave activity was present in the jejunum, but neural responses were poorly developed. By P10, after ICC-DMP developed, both cholinergic excitatory and nitrergic inhibitory neural responses were intact. Muscles of P0 mice were also put into organotypic cultures and treated with a neutralizing Kit antibody. Neural respons...Continue Reading

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Citations

Oct 16, 2008·Cell and Tissue Research·Zheng-Dong QuJohn B Furness
Mar 28, 2008·Purinergic Signalling·J C Bornstein
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Megan F Klemm, Richard J Lang
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Dec 30, 2014·BioMed Research International·Mei LiuZhongping Duan
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Jul 20, 2011·The Journal of Physiology·Mei Hong ZhuKenton M Sanders
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