Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer

Physiological Reviews
Helge Wiig, Melody A Swartz


The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that comprise the cellular microenvironment in tissues. Its alterations are fundamental to changes in cell function in inflammation, pathogenesis, and cancer. Interstitial fluid (IF) is created by transcapillary filtration and cleared by lymphatic vessels. Herein we discuss the biophysical, biomechanical, and functional implications of IF in normal and pathological tissue states from both fluid balance and cell function perspectives. We also discuss analysis methods to access IF, which enables quantification of the cellular microenvironment; such methods have demonstrated, for example, that there can be dramatic gradients from tissue to plasma during inflammation and that tumor IF is hypoxic and acidic compared with subcutaneous IF and plasma. Accumulated recent data show that IF and its convection through the interstitium and delivery to the lymph nodes have many and diverse biological effects, including in ECM reorganization, cell migration, and capillary morphogenesis as well as in immunity and peripheral tolerance. This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its tr...Continue Reading


Jan 1, 1977·Acta Physiologica Scandinavica·G Rutili, K E Arfors
Jan 1, 1977·Annual Review of Physiology·P A Nicoll, A E Taylor
Jan 1, 1978·Physiological Reviews·W D Comper, T C Laurent
Oct 1, 1979·The Journal of Investigative Dermatology·B J VermeerC M van Gent
Jul 1, 1977·Microvascular Research·H O FadnesK Aukland
Jun 1, 1976·The American Journal of Physiology·C R VreimN C Staub
Sep 1, 1976·The American Journal of Physiology·D D Stromberg, C A Wiederhielm
Nov 1, 1976·IEEE Transactions on Bio-medical Engineering·A J Grodzinsky, J R Melcher
May 1, 1975·Journal of Applied Physiology·C E OttF G Knox
Jan 1, 1976·Microvascular Research·A R Hargens, B W Zweifach
Oct 1, 1992·The American Journal of Physiology·H WiigE M Renkin
Apr 1, 1991·Journal of Applied Physiology·J KarpakkaT E Takala
Jul 1, 1991·The American Journal of Physiology·H WiigE M Renkin
Apr 1, 1991·Acta Physiologica Scandinavica·V Aarli, K Aukland
May 1, 1991·Acta Physiologica Scandinavica·V AarliK Aukland
Jun 1, 1991·Journal of Applied Physiology·T R Pitt FordM R Glucksberg
Sep 1, 1991·The American Journal of Physiology·M Gilányi, A G Kovách
Oct 1, 1991·The Journal of Cell Biology·R E MebiusG Kraal
Feb 1, 1991·The American Journal of Physiology·K Aukland
May 1, 1991·The American Journal of Physiology·S J AllenT C Laurent
Dec 1, 1990·Kidney International·E HommelH H Parving
Oct 1, 1990·Physiological Reviews·G W Schmid-Schönbein
Jan 1, 1990·The American Journal of Physiology·N MatsumotoN C Staub
Dec 1, 1989·The American Journal of Physiology·R K ReedH Wiig
Dec 1, 1989·The American Journal of Physiology·R K ReedJ L Bert
Apr 1, 1989·The American Journal of Physiology·T LundR K Reed
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S R Chary, R K Jain
Nov 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R FleischmajerB R Olsen
Nov 1, 1988·The American Journal of Physiology·T LundR K Reed
Nov 1, 1988·Acta Physiologica Scandinavica·R K ReedT C Laurent
Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Jan 1, 1988·Journal of Biomechanics·H OxlundA Viidik
Sep 1, 1988·The American Journal of Physiology·M GilányiA G Kovách
Dec 1, 1987·The American Journal of Physiology·R J Mullins, R W Hudgens
May 1, 1987·The American Journal of Physiology·D C Zawieja, B J Barber

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