Interstitial fluid: the overlooked component of the tumor microenvironment?

Fibrogenesis & Tissue Repair
Helge WiigRolf Bjerkvig

Abstract

The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this compartment may provide important insight into how tumors develop and how they respond to therapy. We discuss available techniques for interstitial fluid isolation and implications of recent findings with respect to transcapillary fluid balance and uptake of macromolecular therapeutic agents. By the development of new methods it is emerging that local gradients exist in signaling substances from neoplastic tissue to plasma. Such gradients may provide new insight into the biology of tumors and mechanistic aspects linked to therapy. The emergence of sensitive proteomic technologies has made the interstitial fluid compartment in general and that of tumors in particular a highly valuable source for tissue-specific proteins that may serve as biomarker candidates. Potential biomarkers will appear locally at high concentrations in the tissue of interest and will eventually appear in the plasma, where they are diluted. Acce...Continue Reading

References

Jan 1, 1978·Physiological Reviews·W D Comper, T C Laurent
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·O W PetersenM J Bissell
May 1, 1991·Acta Physiologica Scandinavica·V AarliK Aukland
Aug 1, 1990·The Biochemical Journal·W D Comper, O Zamparo
Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·R LagacéT A Seemayer
May 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·K Aukland
Jan 1, 1966·Progress in Experimental Tumor Research·P M Gullino
Jul 1, 1981·Physiological Reviews·K Aukland, G Nicolaysen
Jan 1, 1982·Rheumatology International·C J KirkpatrickO Haferkamp
Feb 1, 1994·Psychological Reports·J Sancho-Aldridge, B Gunter
Jan 1, 1994·Physiological Reviews·B Rippe, B Haraldsson
Jul 22, 1993·Annals of the New York Academy of Sciences·A M Zardetto-SmithA K Johnson
Jan 1, 1993·Physiological Reviews·K Aukland, R K Reed
Jul 3, 1999·Physiological Reviews·C C Michel, F E Curry
Aug 31, 1999·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·D O BatesB Williams
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S NiewieskV ter Meulen
Dec 8, 2000·Advanced Drug Delivery Reviews·J Chu, J M Gallo
Dec 8, 2000·Advanced Drug Delivery Reviews·G Boschi, J Scherrmann
Feb 15, 2001·Nature Medicine·S A StackerM G Achen
May 18, 2001·Nature·L A Liotta, E C Kohn
Apr 27, 2002·Science·Timothy P PaderaRakesh K Jain
Jun 5, 2002·Annual Review of Biochemistry·Jeffrey D Esko, Scott B Selleck
Jul 24, 2002·European Journal of Clinical Pharmacology·Martin Brunner, Markus Müller
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Helge WiigOlav Tenstad
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
Jun 5, 2003·Nature Reviews. Cancer·Raghu Kalluri
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Charlotta DabrosinJack Gauldie
Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Helge WiigPer Ole Iversen

❮ Previous
Next ❯

Citations

Aug 25, 2011·Expert Reviews in Molecular Medicine·Kornelia KisJames S Hagood
May 15, 2013·Journal of the National Cancer Institute·Stacey D Finley, Aleksander S Popel
Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Alton B Farris, Robert B Colvin
Nov 23, 2011·BMC Systems Biology·Stacey D FinleyAleksander S Popel
May 2, 2012·The AAPS Journal·Stacey D Finley, Aleksander S Popel
Sep 10, 2011·Drugs·Natalie J Carter
Nov 5, 2013·Cancer Letters·Ling-Jung WangJeng-Woei Lee
May 5, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Tamal DasSuman Chakraborty
Oct 13, 2015·Biochimie·Alejandro Gomez-AuliOliver Schilling
Apr 14, 2011·The Journal of Physiology·Helge Wiig
Feb 19, 2013·Biochimica Et Biophysica Acta·Pavel GromovJosé M A Moreira
Feb 5, 2013·Biochimica Et Biophysica Acta·Hanne Haslene-HoxHelge Wiig
Aug 6, 2014·Scientific Reports·Marija MojićIvan Spasojević
Aug 19, 2014·BioMed Research International·Masayuki NagahashiToshifumi Wakai
Apr 4, 2015·Seminars in Cancer Biology·Annunziata Gloghini, Italia Bongarzone
Jun 16, 2015·Frontiers in Oncology·Marek Wagner, Helge Wiig
Dec 30, 2014·Trends in Cell Biology·Florian Klemm, Johanna A Joyce
May 20, 2016·Journal of Mammary Gland Biology and Neoplasia·Masayuki NagahashiKazuaki Takabe
Oct 18, 2016·Journal of Cellular Biochemistry·Sadhvi NithiananthanSimon A Whawell
Nov 22, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maria-Angeles AllerJaime Arias
Nov 1, 2011·The Journal of Biological Chemistry·Maryline HavardThierry Tchénio
Sep 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·L J LiuM Schlesinger
Dec 14, 2018·International Journal of Molecular Sciences·Blendi UraGiuseppe Ricci
Sep 16, 2017·Mediators of Inflammation·Junko TsuchidaToshifumi Wakai
Aug 23, 2019·Advanced Materials·You YuAli Javey
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Faisal RazaLiang Ge

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsies
xenografts
electrophoresis
bronchoalveolar lavage

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.