Interstitial laser-induced thermotherapy: influence of carbonization on lesion size

Lasers in Surgery and Medicine
C Sturesson

Abstract

The size of laser-induced coagulated lesions produced in porcine muscle in vitro using a cylindrical diffusing fiber tip and a conductive heat source, made by covering the diffuser with a hollow steel needle, were compared to investigate the influence of charring. Light from a Nd:YAG laser was utilized for thermotherapy. A theoretical model for calculating tissue temperature was used to predict the experimental results and to simulate in vivo treatments. The metal-covered tip produced carbonization and tissue vaporization that was not found with the diffuser. After 20 min of irradiation at a laser power of 7 W, the coagulated volumes with and without carbonization were found to be 13.1 cm3 (range 12.4-14.1 cm3, n = 4) and 12.2 cm3 (range 11.5-13.4 cm3, n = 4), respectively. Mathematical simulations showed that in unperfused tissue, a diffusing laser heat source produces smaller lesions than does a conductive heat source at the same power, the difference in coagulated volume becoming smaller with increased treatment time and increased power. Using cylindrical diffusers, interstitial laser-induced thermotherapy without carbonization at the fiber tip can be as efficient as treatment with carbonization.

References

Feb 1, 1992·The British Journal of Surgery·A C StegerS G Bown
Aug 5, 1989·BMJ : British Medical Journal·A C StegerS G Bown
Jul 1, 1988·Radiology·F A JoleszG J Jako
Jan 1, 1987·Lasers in Surgery and Medicine·S L Jacques, S A Prahl
Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Nov 1, 1994·The British Journal of Surgery·S A HarriesS G Bown
Nov 1, 1994·Medical Physics·D R Wyman, W M Whelan
Jan 1, 1994·Lasers in Surgery and Medicine·D WymanK Adams
Jan 1, 1994·Lasers in Surgery and Medicine·R van HillegersbergO T Terpstra
May 1, 1993·IEEE Transactions on Bio-medical Engineering·S A HaiderR B Roemer
Feb 1, 1993·IEEE Transactions on Bio-medical Engineering·G L LeCarpentierA J Welch
Jul 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·E G MorosK Hynynen
Jul 15, 1997·The Journal of Surgical Research·C SturessonS Andersson-Engels
Aug 1, 1948·Journal of Applied Physiology·H H PENNES
Jun 15, 1989·Applied Optics·P ParsaN S Nishioka

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Citations

Feb 21, 2009·Gastrointestinal Endoscopy·Michael B WallaceUNKNOWN EUS 2008 Working Group
Jul 9, 2002·Applied Optics·Limin TongEric Mazur
Jun 15, 2007·American Journal of Surgery·Sean GarreanN Joseph Espat
Aug 29, 2003·The British Journal of Surgery·M Nikfarjam, C Christophi
Jan 22, 2011·Lasers in Surgery and Medicine·Christian SturessonKarl-Göran Tranberg
Dec 18, 2009·Journal of Surgical Oncology·Srikanth PadmaDavid A Iannitti
Apr 12, 2005·American Journal of Surgery·Robert C G Martin
Jun 3, 2016·Lasers in Surgery and Medicine·Vivek Krishna Nagarajan, Bing Yu
Jun 15, 2017·Journal of Functional Biomaterials·Emiliano SchenaYuman Fong
Apr 14, 1999·The British Journal of Surgery·J HeisterkampJ N Ijzermans
Jan 11, 2020·Lasers in Surgery and Medicine·Vivek Krishna NagarajanBing Yu
Feb 27, 2001·Journal of Surgical Oncology·V Muralidharan, C Christophi
May 23, 2002·Current Problems in Surgery·Steven A CurleyLee M Ellis
Jun 9, 2021·CNS Neuroscience & Therapeutics·Wei ShanQun Wang

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