Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival

European Journal of Radiology
Mizuki NishinoBruce E Johnson

Abstract

Interstitial lung diseases are associated with increased risk of lung cancer. The prevalence of ILA at diagnosis of advanced non-small-cell lung cancer (NSCLC) and its impact on overall survival (OS) remain to be investigated. The study included 120 treatment-naïve stage IV NSCLC patients (53 males, 67 females). ILA was scored on CT prior to any systemic therapy using a 4-point scale [0=no evidence of ILA, 1=equivocal for ILA, 2=suspicious for ILA, 3=ILA] by a sequential reading method previously reported. ILA scores of 2 or 3 indicated the presence of ILA. ILA was present in 17 patients (14%) with advanced NSCLC prior to any treatment (score3: n=2, score2: n=15). These 17 patients were significantly older (median age: 69 vs. 63, p=0.04) and had a heavier smoking history (median: 40 vs. 15.5 pack-year, p=0.003) than those with ILA score 0 or 1. Higher ILA scores were associated with shorter OS (p=0.001). Median OS of the 17 patients with ILA was 7.2 months [95%CI: 2.9-9.4] compared to 14.8 months [95%CI: 11.1-18.4] in patients with ILA score 0 or 1 (p=0.002). In a multivariate model, the presence of ILA remained significant for increased risk for death (HR=2.09, p=0.028) after adjusting for first-line systemic therapy (chemothe...Continue Reading

References

Apr 12, 2002·Chest·Demosthenes BourosKyriaki Zeibecoglou
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 14, 2004·Chest·C Martin TammemagiPaul Kvale
Sep 29, 2009·Academic Radiology·George R WashkoHiroto Hatabu
Mar 11, 2011·The New England Journal of Medicine·George R WashkoUNKNOWN COPDGene Investigators
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hirotsugu KenmotsuNobuyuki Yamamoto
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman
Oct 25, 2011·Paediatric Respiratory Reviews·Nadia NathanAnnick Clement
Jan 24, 2012·American Journal of Respiratory and Critical Care Medicine·Tracy J DoyleUNKNOWN COPDGene Investigators
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Nov 7, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Luca VoltoliniGiuseppe Gotti
Jan 3, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takehiko KobayashiMotokazu Kato
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 16, 2013·European Journal of Radiology·Mizuki NishinoHiroto Hatabu
Feb 20, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daichi FujimotoYukihiro Imai
May 23, 2013·The New England Journal of Medicine·Gary M HunninghakeDavid A Schwartz
Jun 7, 2013·Oncology Letters·Takashi KinoshitaTomoaki Hoshino
Nov 10, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Atsuya TakedaEtsuo Kunieda
Nov 26, 2013·The Journal of Thoracic and Cardiovascular Surgery·Toshihiko SatoUNKNOWN Japanese Association for Chest Surgery

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Citations

Jun 29, 2016·Journal of Cancer Research and Clinical Oncology·Nobuhiro KanajiShuji Bandoh
Jul 22, 2016·International Journal of Molecular Sciences·Yong TanAiping Lu
Jun 26, 2018·Current Opinion in Pulmonary Medicine·Mario SilvaNicola Sverzellati
Feb 23, 2019·Japanese Journal of Clinical Oncology·Hisao HigoKatsuyuki Kiura
Mar 11, 2020·Journal of Clinical Medicine·Quentin GibiotJean-Marc Naccache
Jan 24, 2019·American Journal of Respiratory and Critical Care Medicine·Rachel K PutmanGary M Hunninghake
Jun 24, 2015·Cancer Immunology Research·Sree Harsha TirumaniMizuki Nishino
Feb 13, 2016·Cancer Immunology Research·Mizuki NishinoMark M Awad
Jan 21, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Tomoyuki HidaHiroto Hatabu
Feb 28, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christopher D GoodmanUNKNOWN International Association for the Study of Lung Cancer Advanced Radiation Technology Committee
Aug 14, 2019·Chest·Stacey-Ann Whittaker BrownJuan Wisnivesky
Aug 11, 2021·Radiology·Akinori HataHiroto Hatabu

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