Interstitial Lung Disease in Polymyositis and Dermatomyositis

Clinics in Chest Medicine
Kathryn Long, Sonye K Danoff

Abstract

The idiopathic inflammatory myopathies (IIMs), including polymyositis (PM) and dermatomyositis (DM), are autoimmune connective tissue diseases with variable degrees of muscle inflammation and systemic involvement. Interstitial lung disease (ILD) is a common complication of the IIMs and is associated with increased mortality. Many patients with PM/DM have myositis-specific and myositis-associated antibodies (MSA/MAAs) that result in distinct clinical phenotypes. Among these MSAs, anti-aminoacyl-tRNA antibodies and anti-melanoma differentiation factor 5 antibodies have high rates of ILD. Corticosteroids are the mainstay of treatment, although the addition of other immunosuppressive therapy is typically necessary to achieve disease control.

Citations

Feb 11, 2021·Chest·Samuel C Fox, Abhaya P Trivedi
Nov 26, 2020·Journal of Community Hospital Internal Medicine Perspectives·Ana StarkJerrica Mueller
Mar 30, 2021·Frontiers in Immunology·Joao Pedro LopesCharlotte Cunningham-Rundles
May 1, 2021·Medicina·Tomoyuki Fujisawa
May 25, 2021·Clinics in Chest Medicine·Leticia Kawano-Dourado, Joyce S Lee
Dec 4, 2021·Nature Reviews. Disease Primers·Ingrid E LundbergFrederick W Miller

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