PMID: 2260083Jan 1, 1990

Interstitial macrophage subpopulations: responsiveness to chemotactic stimuli

Tissue & Cell
D B Chandler, A L Brannen

Abstract

Recent data suggest that interstitial macrophages are a heterogeneous group of cells with several subpopulations. This study was undertaken to determine if there is heterogeneity among rat interstitial macrophage subpopulations ability to respond to chemotactic stimuli. Alveolar macrophages were harvested and separated into density-defined fractions by centrifugation through a continuous iso-osmotic gradient of colloidal silica. Unfractionated and density-defined interstitial macrophages were then characterized as to their ability to migrate towards F-Met-Leu Phen and zymosan activated serum. Interstitial macrophages of density 1.053 and 1.083-1.097 gm/ml were found to have the greatest migrational movement towards F-Met-Leu-Phen which was lower than the unfractionated population. Interstitial macrophage subpopulations migrational movement towards zymosan activated serum exhibited a major peak by macrophages of density 1.053 gm/ml and a minor peak by macrophages of density 1.083-1.097 gm/ml which was lower than the unfractionated population. These results demonstrated that interstitial macrophages are heterogeneous in their migrational ability towards the chemotactic stimuli F-Met-Leu-Phen and zymosan activated serum and that t...Continue Reading

References

Mar 1, 1975·The Anatomical Record·S P Sorokin, J D Brain
Oct 1, 1988·The American Review of Respiratory Disease·D B ChandlerW C Fuller
Jan 1, 1985·International Archives of Allergy and Applied Immunology·R van Furth
Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Y LiL T Yam
Dec 1, 1982·The Australian Journal of Experimental Biology and Medical Science·P G HoltJ M Papadimitriou
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Apr 1, 1982·Immunobiology·A Blussé van Oud Alblas, R van Furth

Citations

Jan 6, 2005·European Radiology·Katharina Marten, David M Hansell
Apr 20, 2018·Journal of Immunology Research·Theodore S KapellosJoachim L Schultze
Jun 2, 2018·Journal of Immunology Research·Joey SchynsThomas Marichal

Related Concepts

Serum Proteins
Cell Separation
Chemotaxis
Lung
Macrophage
F-Met-Leu-Phe
Polypeptides
Rats, Inbred F344
Zymosan

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