Interstitial permeability and elasticity in human cervix cancer

Microvascular Research
Michael MilosevicRichard P Hill

Abstract

Malignant tumors are characterized by abnormalities of the vasculature and interstitium, which may impede the distribution of drugs and imaging agents. Here we describe a method for estimating tumor interstitial permeability and elasticity based on fitting a spatio-temporal fluid dynamic model to the time course of interstitial pressure (IFP) measurements. The model assumes that sudden insertion of the IFP measurement needle transiently perturbs the steady-state fluid balance, which recovers over time as a function of the vascular and interstitial hydraulic conductivities (L(p)S and K), the interstitial bulk modulus (E) and the extracellular, extravascular volume fraction (phi). Initial simulations showed that the time course of IFP recordings was mainly determined by K and E/phi. Mean values of K and E/phi in 60 newly diagnosed cervix cancers were 1.5 x 10(-7) (SE 2.2 x 10(-8)) cm(2)/mm Hg s and 2230 (SE 212) mm Hg, respectively. For comparison, K and E/phi were also measured in orthotopic ME-180 human cervix cancer xenografts and KHT-C fibrosarcomas in mice. K was higher in both of these tumors (7.0 x 10(-7) and 9.3 x 10(-7)) than in cervix cancer, and E/phi was lower (497 and 433). To our knowledge, these are the first measu...Continue Reading

References

Jan 1, 1990·Ultrasound in Medicine & Biology·K J ParkerR M Lerner
Jul 1, 1970·Journal of Biomechanics·H MetzA K Ommaya
Aug 1, 1966·Circulation Research·A C GuytonD Murphree
May 5, 2001·British Journal of Cancer·K De JaegerR P Hill
Apr 27, 2002·Science·Timothy P PaderaRakesh K Jain
Jun 29, 2004·Microvascular Research·Houman KhosravaniKenneth H Norwich
Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Jul 16, 2004·Seminars in Radiation Oncology·Cornelia LeoNicholas C Denko
Jul 16, 2004·Seminars in Radiation Oncology·Michael MilosevicRichard Hill
Sep 25, 2004·Clinical & Experimental Metastasis·Rob A Cairns, Richard P Hill
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Aug 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anthony FylesRichard P Hill
Feb 20, 2007·Microvascular Research·Jianbing ZhaoMalisa Sarntinoranont

❮ Previous
Next ❯

Citations

Dec 18, 2008·Future Oncology·Sarah Jane LuntMichael Milosevic
Jan 26, 2016·Ultrasound in Medicine & Biology·Anuj ChaudhryRaffaella Righetti
Jan 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Kristine GulliksrudEinar K Rofstad
Mar 23, 2010·Mathematical Biosciences·George E KapellosAlkiviades C Payatakes
Oct 4, 2012·IEEE Transactions on Medical Imaging·Anuj ChaudhryRaffaella Righetti
Mar 11, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rasha ElmghirbiJames R Ewing
Nov 30, 2019·Nature Reviews. Cancer·Gautier FollainJacky G Goetz
Dec 29, 2017·Bulletin of Mathematical Biology·Andrijana BurazinSiv Sivaloganathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.