Abstract
Photodynamic therapy (PDT) is an effective treatment modality that allows selective destruction of malignant tumor cells. However, because of the difficulty in exposing deeper areas of tumors, the modality has strictly limited indications. In this study, the authors introduce a new method for delivering laser light to a three-dimensional, wide area with the purpose of improving the therapeutic value of PDT. Three patients with squamous cell carcinoma of the tongue were treated with the present course. After administering porfimer sodium, laser-proof tubes were inserted through the tumor, and optical fibers were passed through the tubes. Pulse laser was emitted from the obliquely prepared fiber tip and distributed toward the target area while rotating and reciprocating the optical fiber. Two patients achieved a complete response without any complications or functional disabilities. The third patient, however, had a partial response and required surgery. The results indicate the capability of distributing laser light to an entire area of solid tumor. However, the ideal dose of laser light for the treatment of tumors remains unknown. Interstitial PDT will be more efficacious and reliable after the dosimetry is established.
References
Feb 1, 1992·Japanese Journal of Cancer Research : Gann·T OkunakaK Aizawa
Jan 1, 1991·Acta Oto-laryngologica·A F JefferisM C Berenbaum
Jan 1, 1990·Acta Oto-laryngologica. Supplementum·J F Willott
Mar 1, 1990·Japanese Journal of Cancer Research : Gann·N YumitaS Umemura
Nov 1, 1990·Archives of Otolaryngology--head & Neck Surgery·B L WenigE L Appelbaum
Aug 1, 1989·British Journal of Cancer·D Ash, S B Brown
Nov 1, 1986·Archives of Otolaryngology--head & Neck Surgery·D M HarrisS M Waldow
Jun 1, 1985·Archives of Otolaryngology·D E SchullerR P Rock
Dec 2, 1972·Lancet·I DiamondR Jaenicke
Feb 16, 1995·The New England Journal of Medicine·J A BrennanD Sidransky
Feb 1, 1995·Japanese Journal of Cancer Research : Gann·Y HashimotoN Yamaguchi
Aug 1, 1994·Cancer·E W OdellP R Morgan
Nov 1, 1993·Japanese Journal of Cancer Research : Gann·H KatoH Hisazumi
Dec 1, 1993·The Journal of Laryngology and Otology·W E GrantS G Bown
Feb 1, 1994·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·T KiritaM Sugimura
Jun 1, 1993·British Journal of Cancer·C P LowdellS B Brown
Feb 1, 1996·The British Journal of Oral & Maxillofacial Surgery·T W PoateG S Kenyon
Jan 1, 1996·Ultrasound in Medicine & Biology·A G Doukas, T J Flotte
Sep 18, 1997·The Laryngoscope·J L GluckmanP Gartside
Apr 29, 1998·American Journal of Surgery·P W YuenL K Lam
Oct 1, 1996·Journal of Clinical Laser Medicine & Surgery·M A Biel
Jul 14, 1999·Head & Neck·R H SpiroA G Huvos
Citations
Nov 19, 2002·Clinics in Dermatology·Katrin A Salva
Sep 1, 2005·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata
May 9, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tej B ShresthaStefan H Bossmann
Aug 30, 2012·The Journal of Trauma and Acute Care Surgery·Tianhong DaiMichael R Hamblin
Oct 23, 2003·Lasers in Surgery and Medicine·Alexander C KüblerJ-H Fischer
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Paulo Emilio FeuserPedro Henrique Hermes de Araújo
Feb 1, 2020·Photochemistry and Photobiology·Michele M Kim, Arash Darafsheh
Feb 1, 2004·HNO·C S Betz, A Leunig
Dec 6, 2001·Current Oncology Reports·Merrill A Biel
Dec 6, 2020·Biomaterials·Qi ZhuangZhuang Liu