PMID: 11335905May 4, 2001Paper

Interstitial photodynamic therapy with rotating and reciprocating optical fibers

Cancer
H TanakaT Hirano

Abstract

Photodynamic therapy (PDT) is an effective treatment modality that allows selective destruction of malignant tumor cells. However, because of the difficulty in exposing deeper areas of tumors, the modality has strictly limited indications. In this study, the authors introduce a new method for delivering laser light to a three-dimensional, wide area with the purpose of improving the therapeutic value of PDT. Three patients with squamous cell carcinoma of the tongue were treated with the present course. After administering porfimer sodium, laser-proof tubes were inserted through the tumor, and optical fibers were passed through the tubes. Pulse laser was emitted from the obliquely prepared fiber tip and distributed toward the target area while rotating and reciprocating the optical fiber. Two patients achieved a complete response without any complications or functional disabilities. The third patient, however, had a partial response and required surgery. The results indicate the capability of distributing laser light to an entire area of solid tumor. However, the ideal dose of laser light for the treatment of tumors remains unknown. Interstitial PDT will be more efficacious and reliable after the dosimetry is established.

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Citations

Nov 19, 2002·Clinics in Dermatology·Katrin A Salva
Sep 1, 2005·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata
May 9, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tej B ShresthaStefan H Bossmann
Aug 30, 2012·The Journal of Trauma and Acute Care Surgery·Tianhong DaiMichael R Hamblin
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Paulo Emilio FeuserPedro Henrique Hermes de Araújo
Feb 1, 2020·Photochemistry and Photobiology·Michele M Kim, Arash Darafsheh
Dec 6, 2001·Current Oncology Reports·Merrill A Biel

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